Body Weight
Conditions
Keywords
Body weight changes, Medicine, Traditional, Herbal medicine, Rhus, Waist Circumference, Waist-Hip Ratio, Body mass index
Brief summary
The aim of this study is to evaluate the effects of Rhus coriaria L. (Rhus) commonly known as Somagh on body weight.
Detailed description
Rhus coriaria L.(Rhus) is a well-known spice widely consumed in the world which has also been utilized extensively for medicinal purposes. The antioxidant components of this plant made it a favorable target for laboratory and animal studies in different conditions such as oxidative stress cytotoxicity, diabetes and hyperlipidemia. Rhus (Somagh) is found in temperate and tropical regions worldwide, often growing in areas of marginal agricultural capacity. Rhus is used as an herbal remedy in traditional medicine because of its assumed analgesic, antidiarrheic, antiseptic, anorexic and antihyperglycemic properties. The fruits of Rhus contain flavonols, phenolic acids, hydrolysable tannins, anthocyans and organic acids such as malice, citric and tartaric acids. Some studies have shown that polyphenols could have beneficial effects on cardiovascular disease and cancer and could be regarded as bioactive compounds with a high potential health-promoting capacity. Phenolic compounds inhibit lipid peroxidation, scavenge the superoxide anion and hydroxyl radical, and enhance the activities of detoxifying enzymes. The aim of this study is to evaluate the effects of Rhus coriaria L. (Rhus) commonly known as Somagh on body weight.
Interventions
DRUGRhus Coriaria L.(Rhus)
500 mg twice daily after meals for 6 weeks
DRUGPlacebo
500 mg twice daily after meals for 6 weeks
Sponsors
Shiraz University of Medical Sciences
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Body mass index (BMI) \>= 25 kg/m2
Exclusion criteria
* Diabetes mellitus * Hypo. or hyperthyroidism * Any systemic illnesses e.g. liver cirrhosis, acute or chronic renal failure, heart failure * Use of drugs: Weight lowering agents, glucocorticoids, Oral contraceptive pills. * Pregnancy * History of allergic reaction to Somagh
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Body Mass Index | 6 weeks |
Secondary
| Measure | Time frame |
|---|---|
| Hip Circumference (cm) | 6 weeks |
| Leptin (ng/ml) | 6 weeks |
| Waist Circumference (cm) | 6 weeks |
| Fasting Blood Glucose (mg/dl) | 6 weeks |
| Number of patients with adverse event | 6 weeks |
| Insulin (mU/l) | 6 weeks |
Countries
Iran
Outcome results
None listed