Healthy Subjects
Conditions
Brief summary
Self-reported healthy participants (n=150) aged 30-65 years with 18.5 kg/m\^2 ≤ BMI \< 30 kg/m\^2 were randomly assigned into three groups: a low linoleic acid (LA, 18:2n-6) group (n=50) replaced 10 mL soy oil with one apple; a medium LA group (control group, n=50) maintained usual food intake; a high LA group (n=50) reduced 1/3 cup of cooked refined rice and consumed 9.9g of soy oil capsules daily as a supplement. Plasma fatty acids and lipoprotein-associated phospholipase A2 (Lp-PLA2) activity were measured at baseline and 8 week alongside other cardiovascular disease risk factors.
Interventions
DIETARY_SUPPLEMENTLow LA
Individuals who replaced 10 mL soy oil with one apple
DIETARY_SUPPLEMENTHigh LA
Individuals who reduced 1/3 cup of cooked refined rice and consumed 9.9g (9 of 1.1g capsules, 3 capsules at every 3 meals a day) of soy oil as a supplement
Sponsors
Yonsei University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
30 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Age 30 to 65 years at beginning of study * Subjects with BMI 18.5 to 30 kg/m\^2
Exclusion criteria
* Use of any medication or supplements that alter lipid metabolism. * Presence of dyslipidemia, diabetes mellitus, hypertension, liver disease, renal disease, chronic disease of the gastrointestinal tract, cerebrovascular disease, pancreatitis or cancer. * Women who pregnant or lactating. * Drug or alcohol abuse.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in Lp-PLA2 activity (nmol/mL/min) | At baseline and end of each 8-week diet period |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in total cholesterol (mg/dL) | At baseline and end of each 8-week diet period | — |
| Change in LDL cholesterol (mg/dL) | At baseline and end of each 8-week diet period | Lipids and lipoproteins, such as total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides, Apo A-I, Apo B |
| Change in HDL cholesterol (mg/dL) | At baseline and end of each 8-week diet period | — |
| Change in triglyceride (mg/dL) | At baseline and end of each 8-week diet period | — |
Countries
South Korea
Outcome results
None listed