Dexmedetomidine on Optic Nerve Sheath Diameter

Effect of Dexmedetomidine on Optic Nerve Sheath Diameter During Laparoscopic Anterior Resection

Status

Withdrawn

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02753205

Enrollment

Registered

2016-04-27

Start date

2016-04-30

Completion date

2018-04-30

Last updated

2016-11-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intracranial Hypertension

Brief summary

Dexmedetomidine, might attenuate the sympathetic activation and contribute to stable hemodynamics. The investigator hypothesized that continuous infusion of dexmedetomidine during laparoscopic lower abdominal surgery, might help to attenuate the increment of intracranial pressure and the investigator would observe the optic nerve sheath diameter using ultrasonography.

Detailed description

Laparoscopic lower abdominal surgery requires the Trendelenburg position with pneumoperitoneum for a prolonged time, but this can cause significant increase in intracranial pressure. Dexmedetomidine, a selective alpha2 receptor agonist might attenuate the sympathetic activation and contribute to stable hemodynamics. The investigator hypothesized that continuous infusion of dexmedetomidine during laparoscopic lower abdominal surgery, might help to attenuate the increment of intracranial pressure and the investigator would observe the optic nerve sheath diameter using ultrasonography.

Interventions

DRUGDexmedetomidine

infusion of dexmedetomidine 0.5ug/kg/h for 10 min and after that, infusion of dexmedetomidine 0.4ug/kg/h until the end of surgery

DRUGnormal saline

infusion of normal saline

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SUPPORTIVE_CARE

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

20 Years to 65 Years

Healthy volunteers

Inclusion criteria

* clinical diagnosis of colorectal cancer * planed for laparoscopic low anterior resection

Exclusion criteria

* morbid obesity (body mass index \> 30 kg.m-2) * history of cerebrovascular disease * history of respiratory disease * uncontrolled cardiovascular disease

Design outcomes

Primary

Measure	Time frame	Description
Optic nerve sheath diameter	Change from Baseline optic nerve sheath diameter at pneumoperitoneum 30 min	mm

Secondary

Measure	Time frame	Description
Respiratory and mean arterial pressure	Change from Baseline Respiratory and mean arterial pressure at pneumoperitoneum 30 min	mmHg

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026