Consumption of Probiotics on Salivary Bacteria Causing Dental Caries

Evaluation of the Consumption of Probiotics on the Bacteria Causing Dental Caries: A Randomised Clinical Trial

Status

Completed

Phases

Phase 2Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02752594

Enrollment

Registered

2016-04-27

Start date

2015-04-30

Completion date

2015-04-30

Last updated

2016-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dental Caries

Keywords

probiotic, mutans streptococci, bacillus coagulans, caries

Brief summary

Dental caries is a multifactorial disease effecting majority of the human population.One of the etiological factor causing dental caries is salivary mutans streptococci. Reducing the levels of this bacteria in the saliva can significantly reduce the incidence of dental caries. A non-invasive intervention, such as the administration of probiotics reduced the salivary mutans streptococci levels.

Detailed description

40 candidates were selected from a pre-determined group and were randomly assigned to two groups. Group A (n=20) was administered probiotic drink and Group B (n=20) was administered placebo for 14 consecutive days. Saliva was collected on day 1 and day 15 to compare the salivary mutans streptococci levels.

Interventions

BIOLOGICALprobiotic

Probiotic was administered for a period of 14 consecutive days. Saliva was collected on Day 1, before intervention and on Day 15, after intervention

OTHERplacebo

placebo was administered for a period of 14 consecutive days. Saliva was collected on Day 1, before intervention and on Day 15, after intervention

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

20 Years to 25 Years

Healthy volunteers

Yes

Inclusion criteria

* Decayed Missing Filled Surfaces less than or equal to 6 * Brushes twice daily

Exclusion criteria

* undergoing orthodontic treatment * topical fluoride therapy in the past 2 yrs * using sugar free gums

Design outcomes

Primary

Measure	Time frame	Description
counts of streptococcus mutans after the consumption of probiotic	15 days	Human saliva was assessed for the counts of streptococcus mutans, one of the major etiological factor for dental caries

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026