Recurrent Implantation Failure
Conditions
Brief summary
300 recurrent implantation failure patients will be alternatively assigned to assisted hatching , endometrial scratch , and no treatment ,100 patients in each group
Detailed description
Group 1 consists of 100 patients will undergo endometrial scratch followed by controlled ovarian hyperstimulation Group 2 consists of 100 patients will undergo controlled ovarian hyperstimulation& assisted hatching Group 3 consists of 100 patients will undergo controlled ovarian hyperstimulation
Interventions
PROCEDUREendometrial scratch
midluteal endometrial scratch using Novak curette under general anesthesia in the cycle preceding stimulation
PROCEDUREassisted hatching
using Octax laser 20120644-laser 5452
PROCEDUREcontrolled ovarian hyperstimulation
using merional&/ or fostimon doses individualized as judged by patient age & ovarian reserve & monitored by follicular size & serum estradiol
Sponsors
Kasr El Aini Hospital
Study design
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* recurrent implantation failure * normal uterine cavity by transvaginal ultrasound
Exclusion criteria
* endometrial polyp or fibroid distorting the endometrium * hydrosalpinx * preimplantation genetic diagnosis * severe male factor
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| number of patients with positive pregnancy test | 2 months |
Contacts
Primary Contactsuzy abdelaziz, lecturer
Outcome results
None listed