The Establishment of Multiple Point Prediction Model About Tacrolimus Metabolic Differences Based on Genetic Network After Liver Transplantation and the Application of Multicenter

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02752529

Enrollment

415

Registered

2016-04-27

Start date

2016-03-31

Completion date

Unknown

Last updated

2016-05-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cirrhosis, Liver

Keywords

Liver Transplantation, Individualized Therapy, Polymorphism

Brief summary

Combined with the clinical data of FK506 and the database of GO and Kyoto Encyclopedia of Genes and Genomes（KEGG）, the investigators aim to carry out the bioinformatic analysis and build a muti-locus genetic model, then muti-center assess the predictive accuracy of FK506 metabolic differences.

Interventions

DRUGTacrolimus（FK506）

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Inclusion criteria

* Clinical diagnosis of end-tage liver diseases * 18 years old or above * Han nationality * Therapeutic regimen：TAC

Exclusion criteria

* Less than 18 years old * Other races * Therapeutic regimen：cyclosporine

Design outcomes

Primary

Measure	Time frame
Area under the plasma concentration versus time curve (AUC) of Tacrolimus	7 days

Countries

China

Contacts

Primary ContactZhihai Peng

pengzh1958@yeah.net0086-13761010066

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026