Anesthesia, Chronic Pain
Conditions
Keywords
Opioid-sparing
Brief summary
The objective of this trial is to determine whether an opioid-free general anesthetic (OFA) technique utilizing ketamine, dexmedetomidine, and lidocaine infusions can help reduce postoperative pain in opiate-dependent chronic pain patients (CPPs) undergoing spine surgery when compared with traditional opioid-containing techniques. It is expected that this OFA regimen will have a measurable reduction on postoperative opioid consumption and pain scores in CPPs.
Interventions
DRUGOpioid-free general anesthetic
An opioid-free general anesthetic technique utilizing dexmedetomidine, ketamine, and lidocaine infusions
DRUGTraditional general anesthetic
Traditional general anesthetic technique utilizing sufentanil, fentanyl or remifentanil
Sponsors
Ben Lim
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Chronic pain \> 6 months, opiate-using patients scheduled for thoracic or lumbar spinal surgery
Exclusion criteria
* Pregnant or breastfeeding women, significant hepatic, renal or cardiac disease, allergy to any of the study drugs, inability to consent, respond to pain assessments or use the patient controlled analgesia device
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quantified opioid-consumption | 48 hours following surgery |
Secondary
| Measure | Time frame |
|---|---|
| Visual analogue scale (VAS) pain scores | 48 hours following surgery |
| Time of stay in post-anesthetic care unit (PACU) | up to 5 hours following surgery |
| Incidence of adverse events | 48 hours following surgery |
Countries
Canada
Outcome results
None listed