Affective Disorders, Anxiety Disorders, Emotions, Inflammation, Mood Disorders, Oxidative Stress, Psychological Stress
Conditions
Brief summary
This study intents to determine who will benefit from an intensive brief stress coping intervention week (ISCIW) as secondary prevention for real world affective disorder patients.
Detailed description
Affective disorders are associated with a substantial personal and socio-economic burden. This study evaluates an intensive brief stress-coping intervention week (ISCIW) as feasible follow-up treatment for real world patients who suffer from this highly prevalent and chronic stress-related disorders. Stress-associated blood (Interleukin-6, Homocystein, Myeloperoxidase), saliva cortisol and psychosocial screening parameters will be analyzed to determine who will benefit from the ISCIW. All patients were identified in a preventive medical screening before pre-treatment for at least three month as outpatient and the following inclusion to the follow-up ISCIW-trial at the Health and Prevention Center, Sanatorium Hera, Vienna, Austria. For the three planed groups and interventions see interventions and arms.
Interventions
BEHAVIORALstress-coping week
The multidisciplinary team will offer Mindfulness-Based Stress Reduction (MBSR), group psychotherapy (resilience, Cognitive Behavioral Analysis System of Psychotherapy CBASP, psychodynamic therapy), relaxation training, nutrition course, stress-coping and physical training in a group setting.
BEHAVIORALadditional two days follow-up weekend
A two-days follow-up which recapitulates previous treatment elements.
Sponsors
Sanatorium Hera Vienna
Medical University of Vienna
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Affective or anxiety disorder DSM-IV diagnosis (structured interview, M.I.N.I. International Neuropsychiatric Interview ) * Minimum 3-weeks previous therapeutic treatment as outpatient at the Health and Prevention Center, Sanatorium Hera, Vienna, Austria * Clinical Global Impression - Severity (CGI-S) score \> 2 points * Minimum improvement of 1 CGI-S points as outpatient * Written informed consent
Exclusion criteria
* More than 60 days away sick per year in the last year before intervention * Therapy adherence as outpatient at the Health and Prevention Center, Sanatorium Hera, Vienna, Austria * Work Ability Index (WAI) score \< 25 points * Major neurological or cognitive deficits * Current psychotic symptoms * Current or previous DSM-IV diagnosis of substance dependence, except for nicotine or current substance abuse * Failures to comply with the study protocol or to follow the instructions of the study team * Currently requested application for retirement * Middle to high suicidal tendency in the M.I.N.I.-examination
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change of saliva cortisol | Change from baseline saliva sample at week 1 to end of study visit at week 38 |
Secondary
| Measure | Time frame |
|---|---|
| Change of myeloperoxidase | Change from baseline at week 1 to end of study visit at week 38 |
| Change of interleukin-6 | Change from baseline at week 1 to end of study visit at week 38 |
| Change of homocystein | Change from baseline at week 1 to end of study visit at week 38 |
| Change of psychometric stress-index (Questionnaire) | Change from baseline at week 1 to end of study visit at week 38 |
Outcome results
None listed