Effects of Acutely Elevated Afterload on Left Ventricular Contractility and Relaxation

Effects of Acutely Elevated Afterload oN Left VentRicular Contractility and RElaxation in Heart Failure With Preserved and Reduced Ejection Fraction

Status

Terminated

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02751853

Acronym

ANREP-EF

Enrollment

Registered

2016-04-26

Start date

2016-12-31

Completion date

2022-08-31

Last updated

2022-09-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart Failure

Brief summary

Aim of the study is to assess the effects of abruptly increased afterload on left ventricular contractility and relaxation in patients with heart failure with preserved ejection fraction (HFPEF), patients with heart failure with reduced ejection fraction (HFREF), and patients without HFPEF or HFREF.

Interventions

DEVICEConductance catheter

Continuous online measurements of left ventricular pressure and volume using conductance catheters

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Clinical indication for left and right heart catheterization * HFPEF (Group 1) OR HFREF (Group 2) OR absent echocardiographic evidence of HFREF OR HFPEF(Group 3) AND * Sinus rhythm during invasive measurements * Age ≥18 years * Negative pregnancy test in women with childbearing potential * Written informed consent

Exclusion criteria

* Acute coronary syndrome * Acute myocardial infarction \<6 months * Planned cardiac surgery or cardiovascular intervention within 6 months following inclusion * Valvular heart disease \>2° * Severe comorbidities with limited life expectancy \<12 months * Precapillary pulmonary hypertension * Participation in another trial

Design outcomes

Primary

Measure	Time frame	Description
Hemodynamic parameter 1: Changes in contractility assessed by the end-systolic pressure-volume relationship	Day 1	Changes in contractility after handgrip exercise assessed by the end-systolic pressure-volume relationship

Secondary

Measure	Time frame	Description
Hemodynamic parameter 2: Changes in contractility assessed by the peak power index	Day 1	Changes in contractility after handgrip exercise assessed by the peak power index
Hemodynamic parameter 3: Changes in relaxation assessed by the relaxation constant tau	Day 1	Changes in relaxation after handgrip exercise assessed by the relaxation constant tau
Functional parameter: Changes in ejection fraction	Day 1	Changes in ejection fraction after handgrip exercise assessed by echocardiography

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026