Diabetes Mellitus
Conditions
Keywords
Diabetes Mellitus, Cataract, Aqueous humor
Brief summary
Comparison of aqueous and plasma glucose level in diabetic patients High glucose concentrations in aqueous humor are thought to be related of diabetic ocular injury, including cataract and diabetic keratopathy. The primary mechanisms are nonenzymatic glycation, oxidative stress and activation of polyol pathway. However, glucose concentrations in aqueous humor of diabetic patients was only examined in a few patients in the past. This study will compare glucose concentration in blood plasma and aqueous humor in diabetic patients undergoing cataract surgery. Perioperative Hemoglobin A1c concentrations will also be examined. Correlation between these parameters will be analyzed.
Interventions
OTHERGlucose measurement
1. Elective cataract surgery 2. Blood glucose measurement - glucometer 3. Aqueous humor glucose measurement - at beginning of cataract surgery - glucometer 4. Perioperative Hemoglobin A1c level - blood laboratory test
Sponsors
Sheba Medical Center
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
\- Diabetic patients planed for elective cataract surgery
Exclusion criteria
* s/p traumatic eye injury * past or current uveitis * patients using prescription eye drops except lubricants
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Aqueous humor glucose concentration | Day of cataract surgery |
Secondary
| Measure | Time frame |
|---|---|
| Plasma glucose concentrations | Day of cataract surgery |
| Hemoglobin A1c | Perioperative month |
Contacts
Primary ContactLior Lipsky, MD
Backup ContactIrit Barequet, MD
Outcome results
None listed