Study of A Special Vessel Subtype in Bone Samples From Patients With Osteoporotic and Nonosteoporotic Fracture

Collection of Bone Specimens for Testing of A Special Vessel Subtype

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02750046

Enrollment

Registered

2016-04-25

Start date

2016-03-31

Completion date

2018-02-28

Last updated

2016-04-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Femoral Neck Fractures

Brief summary

RATIONALE: Collecting and storing bone samples from patients with osteoporotic and nonosteoporotic fracture to study a special vessel subtype in the laboratory may help surgeon learn more about the relationship between bone mineral density (BMD) and a special vessel subtype (type H vessel). PURPOSE: This research study is looking at changes of a special vessel subtype in bone samples from patients with osteoporotic and nonosteoporotic fracture.

Detailed description

OBJECTIVES: 1. Establish type H vessel in bone specimen in patients with hip fracture. 2. Explore the correlation of BMD and type H vessel. OUTLINE: 1. Collect human bone specimens from patients with Osteoporotic and Nonosteoporotic Fracture. 2. Provide a repository for storage of tissue and make these specimens available for approved projects by laboratory-based investigators. 3. Observe the type H vessel in bone slice by immunofluorescence staining. 4. Collect clinical data on these patients including bone mineral density. 5. Investigate the relationship between BMD and type H vessel.

Interventions

PROCEDUREtotal hip arthroplasty or proximal femoral nails

Bone samples from Hip fracture were collected when total hip arthroplasty or proximal femoral nails was performed.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

DIAGNOSTIC

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

FEMALE

Age

60 Years to 75 Years

Healthy volunteers

Inclusion criteria

1. Ages Eligible for Study: 65-75 Years 2. Genders Eligible for Study: Woman 3. Accepts Healthy Volunteers: NO 4. Study Population: Female patients with hip fracture. -

Exclusion criteria

1. Malignancy or benign ovarian cysts 2. Known chronic or systemic diseases 3. Hormone therapy in the previous 3 months 4. Bone metabolism and drug therapy

Design outcomes

Primary

Measure	Time frame	Description
The area of a special vessel subtype in human bone samples	3 months	Bone samples were fixed in 4% PFA, decalcified, dehydrated, embedded and immunofluorescent staining for 3 months. Calculate the proportion of the special vessel of total vessel.

Secondary

Measure	Time frame	Description
The value of bone mineral density	1 week	Bone mineral density was measured by double energy X-ray absorptiometer (DXA) in a week before surgery.
Correlation of of bone mineral density and area of a special vessel subtype in human bone	2 months	Calculate correlation coefficient of BMD and type H vessel in human bone samples in 2 months.

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026