Rosacea
Conditions
Brief summary
Rosacea is a common disease characterized by inflammation and vascular abnormalities of the facial skin and ocular surface. It it considered to be a syndrome encompassing various combinations of cutaneous signs including flushing, erythema, telangiectasia, papules, edema, ocular lesions, and rhinophyma. The exact etiology of cutaneous rosacea is unknown but is characterized by persistent vasodilation, increased vascular permeability, and vascular hyper-reactivity of the microcirculation of the central part of the face. The purpose of this study is to develop gene expression profiles of papulopustular rosacea compared to those of normal skin. The investigator hopes to better understand the abnormal gene functions that might contribute to this condition. This understanding may lead to the development of additional and better treatments for rosacea.
Interventions
OTHERSkin Biopsy
Skin biopsies will be performed via the Keys punch technique from normal facial skin.
Sponsors
Stanford University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
include: 1. Fitzpatrick skin type II or III 2. Age greater than or equal to 18 years 3. Individuals without a history of rosacea
Exclusion criteria
include: 1. Women who are pregnant or lactating 2. Use of topical prescription medications or procedures to the face within one month of enrollment 3. Skin conditions that might interfere with interpretation of procedure results (at the discretion of the investigator)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gene expression profile of papulopustular rosacea compared to normal skin and skin from individuals without rosacea. | Up to 2 years |
Countries
United States
Outcome results
None listed