Hereditary Risk Factors for Thyroid Cancer

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02747888

Enrollment

250

Registered

2016-04-22

Start date

2016-03-01

Completion date

2029-03-01

Last updated

2026-06-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Thyroid Cancer

Keywords

Thyroid

Brief summary

Thyroid cancers can occur sporadically, but can also be found as tumors that cluster in families with other cancers or genetic syndromes. Researchers are studying thyroid cancer in children and families, with a particular interest in understanding genes and other factors that may put individuals at risk for developing thyroid cancer and thyroid nodules. * In this study, family and medical history information is collected alongside a blood or saliva sample for genetic studies. * Individuals with a past or present childhood thyroid cancer/nodule or a thyroid cancer suspected to be inherited in their family are invited to participate.

Detailed description

The purpose of this research study is to learn more about risk factors for inherited thyroid cancer. The investigators would like to use the participant DNA to look for alterations in genes. The investigator will perform DNA sequencing and other genetic studies to identify errors in the genes that may contribute to the formation of thyroid nodules and cancer.

Interventions

GENETIC•Referral to Genetic Counselor, if indicated

Study design

Allocation

NON_RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

SCREENING

Masking

NONE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Yes

Inclusion criteria

* Individual pediatric patient with current or previous known or suspected thyroid cancer or nodule(s). * Individual adult patient with current or previous known or suspected thyroid cancer or nodule(s) if they come from a family with a high suspicion of hereditary cancer (as below). * Individuals from families with a high suspicion of hereditary thyroid cancer: * Families with a current or previous diagnosis of a thyroid cancer/nodule occurring in childhood (\<18 years old). * Families with a high suspicion of hereditary thyroid cancer/nodules other than above to include: * Families with thyroid cancer in multiple individuals * Families with thyroid cancer and a known genetic syndrome * Families with thyroid cancer and a suspected genetic syndrome (e.g. multiple childhood cancers in the family, multiple primary cancers, multiple endocrinopathies, etc.)

Exclusion criteria

* Individuals who are unable to give informed consent. * Individuals who are unable to complete study materials.

Design outcomes

Primary

Measure	Time frame
Number of participants who have childhood or suspected familial thyroid nodules/cancer	2 years
Number of germline mutations identified associated with thyroid cancer predisposition	2 years
Prevalence of suspected familial thyroid cancer among those with childhood thyroid nodules/cancer	2 years

Countries

United States

Contacts

CONTACTJunne Kamihara, MD, PhD

junne_kamihara@dfci.harvard.edu617.632.3044

CONTACTSarah Hunt, MPH

sarah_hunt@dfci.harvard.edu

PRINCIPAL_INVESTIGATORJunne Kamihara, MD, PhD

Dana-Farber Cancer Institute

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jun 12, 2026