Headache, Migraine Disorders
Conditions
Brief summary
Single center, double-blind, randomized, placebo-controlled trial evaluating analog pain scores in patients who present to the emergency department (ED) with a complaint of headache. A total of 150 patients age 13-55 presenting to the emergency department with headache will be enrolled from October 2015 - October 2016. Patients will be randomized and pain scores and side effects will be recorded at 0, 30, 60, and 90 minutes. Follow-up will be performed by telephone at 24 hours.
Interventions
DRUGHaloperidol
DRUGPlacebo
Sponsors
Western Michigan University School of Medicine
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
13 Years to 55 Years
Healthy volunteers
No
Inclusion criteria
* Emergency Department patients that complain of headache or migraine * Males and females age 13-55 * English is primary language
Exclusion criteria
* Abnormal blood pressure (\>200/100) * Sudden rapid onsent (normal to worst pain in minutes) * Fever * Trauma * Any history of masses, strokes, head injury or other causes of abnormal anatomy * QT greater than 450 ms on EKG * Allergy to Haldon * Any altered mental status (GCS \<15) * Pregnancy * Any abnormalities on neurologic exam * Any clinician concern that would require CT scan of brain * Any prisoner or ward of state
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| >50% reduction in pain per Visual Analog Scale (VAS) | 90 minute interval |
Outcome results
None listed