Glucose Metabolism
Conditions
Keywords
GIP, GIP receptor antagonist
Brief summary
Antagonizing GIP effects during hyperglycaemia in healthy subjects and measurements of insulin secretion.
Detailed description
Aim: To evaluate the GIP receptor antagonizing effect of peptide-based competitive GIP receptor antagonist GIP-A (vs. saline (placebo)) in 10 healthy subjects during 1 hour hyperglycaemic clamps with and without concomitant iv infusion of GIP\[1-42\]. The intention is to establish GIP-A as a tool to eliminate glucose-dependent insulinotropic GIP signalling. The study consists of four experimental days (A-D) with assessment of beta cell function during 12 mM-hyperglycaemic clamps with concomitant infusions of A) GIP\[1-42\], B) GIP-A, C) GIP\[1-42\] + GIP-A, or D) saline (placebo).
Sponsors
University of Copenhagen
University Hospital, Gentofte, Copenhagen
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
MALE
Age
20 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
* Normal kidney function, liver function and hemoglobin levels.
Exclusion criteria
* Medication, Diabetes type 1 or 2, BMI \> 25, first degree relatives with Type 2 Diabetes
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Insulin levels | 65 minutes | Serum-insulin AUC (area under the curve for hyperglycemic clamp period) |
Countries
Denmark
Outcome results
None listed