Cognitive Deficits, Proprioceptive Disorders
Conditions
Keywords
NHL, Concussion, Biomarkers
Brief summary
To investigate long term affects of multiple concussions on the cognition, balance, proprioception, and biomarkers in retired National Hockey League players
Detailed description
This research study will collect data for each subject in one single visit. During the visit the subject will be asked to consent to the study which is estimated to take approximately 10 minutes. A medical history will be obtained, taking approximately 15 minutes. Blood, urine, and cheek swabs will be collected for approximately 15 minutes. The PHQ-9, Becks Depression Inventory, Connors Adult ADHD Rating Scale (CAARS™), and Montreal Cognitive Assessment (MoCA) will be administered, these assessments combined are estimated to take 50 minutes. Lastly, patients will be asked to complete a Sensory Organization Test (SOT) which takes approximately 15 minutes. There are only licensed health professionals working on this project that will respect your privacy and conduct this trial following all HIPPA and clinical research guidelines.
Interventions
OTHERSensory Organization Test
Balance and proprioception test
GENETICBiomarkers
Blood, urine, and saliva biomarkers
OTHERConners' Adult ADHD Rating Scale (CAARS)
Adult ADHD rating scale
OTHERDepression Scale
Becks Depression Inventory and Patient Health Questionnaire 9 (PHQ-9)
OTHERCognitive Assessment
Montreal Cognitive Assessment (MoCA)
Sponsors
New York Institute of Technology
Study design
Observational model
CASE_CONTROL
Time perspective
OTHER
Eligibility
Sex/Gender
MALE
Age
40 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Retired professional NHL player * History or reported concussion and concussion like symptoms
Exclusion criteria
* Any neurological condition * Non sport related head trauma
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cognition assessed with the Montreal Cognitive Assessment Scale | 10 minutes | Montreal Cognitive Assessment Scale |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Adult Attention Deficit assessed with the Connors' Adult Attention Deficit Disorder Rating Scale | 10 minutes | Connors' Adult Attention Deficit Disorder Rating Scale |
| Proprioception/Postural Stability assessed with the Sensory Organization Test | 15 minutes | Sensory Organization Test |
| Human Interleukin-6 (IL-6) | 5 Minutes | Blood (20 cc), Urine (40 cc): Total volume for all proposed biomarkers Marker type: Inflammation |
| Patient Health Questionnaire 9 (PHQ-9) | 5 minutes | Self administered screening and diagnostic questionnaire for mental health disorders |
| Interleukin 7 (IL-7) | 5 minutes | Blood (20 cc), Urine (40 cc): Total volume for all proposed biomarkers Marker Type: Inflammation |
| Human 8-hydroxy-2' -deoxyguanosine (8-OHdG) | 5 minutes | Blood (20 cc), Urine (40 cc): Total volume for all proposed Marker Type: Oxidative stress on DNA |
| 3-nitrotyrosine | 5 minutes | Blood (20 cc), Urine (40 cc): Total volume for all proposed Marker Type: Oxidative stress on lipids |
| 8-iso-Prostaglandin F2a | 5 minutes | Blood (20 cc), Urine (40 cc): Total volume for all proposed Marker Type: oxidative stress on lipids |
| Dityrosine | 5 minutes | Blood (20 cc), Urine (40 cc): Total volume for all proposed Marker Type: Oxidative Stress on protein |
| Beck's Depression Inventory | 10 minutes | A 21 question multiple choice self report inventory measuring the severity of depression |
| Complement Component 3 B (C3b) | 5 minutes | Blood (20 cc), Urine (40 cc), Saliva (5 cc): Total volume for all proposed Marker Type: Complement system |
| MicroRNA miR132 | 5 minutes | Blood (20 cc), Urine (40 cc), Saliva (5 cc) Total volume for all proposed Marker Type: MicroRNA |
| MicroRNA miR183 | 5 minutes | Blood (20 cc), Urine (40 cc): Total volume for all proposed Marker Type: MicroRNA |
| S-100B Calcium binding protein | 5 minutes | Blood (20 cc), Urine (40 cc): Total volume for all proposed Marker Type: Blood brain barrier damage |
| Brain derived neurotrophic factor (BDNF) | 5 minutes | Blood (20 cc), Urine (40 cc): Total volume for all proposed Marker Type: Inflammation |
| Amyloid beta 40 | 5 minutes | Blood (20 cc), Urine (40 cc): Total volume for all proposed Marker Type: Neurodegeneration |
| Total Tau Protein (tTAU) | 5 minutes | Blood (20 cc), Urine (40 cc): Total volume for all proposed Marker Type: Traumatic brain injury |
| Eco-Rna Species | 5 minutes | Blood (20 cc), Urine (40 cc),Saliva (5 cc): Total volume for all proposed Marker Type: Exo-RNA |
| Apolipoprotein E-4 | 5 minutes | Blood (20 cc), Urine (40 cc): Total volume for all proposed Marker Type: Traumatic brain injury |
Countries
United States
Outcome results
None listed