Acute Pain, Postoperative
Conditions
Keywords
Elective total knee arthroplasty
Brief summary
The purpose of this study is to compare intravenous (IV) and oral acetaminophen for the treatment of acute moderate to severe pain in combination with standard patient-controlled analgesia (PCA) in adult subjects following total knee replacement.
Interventions
Sponsors
Mallinckrodt
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
50 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
1. Subject must be adequately informed and understand the nature and risks of the study and must be able to provide a signature and date on the informed consent form. 2. Subject must be male or females, between 50 and 90 years of age (inclusive) at Screening. 3. Subject must have a weight range of 50 to 120 kg. 4. Subject must be in a American Society of Anesthesiologists risk class of I, II, or III. 5. Subject must have successfully completed an unilateral uncomplicated total knee replacement surgery, able to take oral medication, and report having moderate to severe acute pain as determined by a pain score ≥ 5 from the 11-point Numeric Pain Rating Scale (NPRS) scale during the period of 3 to 6 hours postsurgery. 6. Female subjects of child-bearing potential must have a negative serum pregnancy test at the Screening and day-of-surgery. 7. Subjects must be able to communicate effectively with study personnel. 8. Subject must be able and willing to follow all protocol requirements, including operating a PCA device, and study restrictions.
Exclusion criteria
1. Subject is from a vulnerable population, as defined by the Code of Federal Regulations Title 45, Part 46, 1. Section 46.111(b), including but not limited to employees (temporary, part-time, full time, etc.) or a family member of the research staff conducting the study, or of the sponsor, or of the clinical research organization, or of the Institutional Review Board. 2. Subject has an oxygen saturation of less than 95% while awake on room air. 3. Subject has a positive test result for human immunodeficiency virus, hepatitis B (surface antigen), or hepatitis C virus antibody at Screening. 4. Subject has used an average of 30 mg oral morphine equivalents or greater, 1 to 2 weeks prior to the day of surgery. Subjects who, in the investigator's opinion are developing opioid tolerance will be excluded. 5. Subject has a history of any drug allergy, hypersensitivity, or intolerance to acetaminophen or morphine or to any of the excipients in the IV or oral formulations used. 6. Subject has intra- or postoperative complications, which in the view of the investigator, makes the subject unsuitable for the participation of the study. 7. Subject has received neuraxial (spinal or epidural) opioid injected perioperatively. 8. Subject has received a local anesthetic, regional, or wound injection or continuous infusion by any route. 9. Subject has impaired liver function (eg, aspartate aminotransferase, alanine aminotransferase, or bilirubin greater than or equal to 3.0 times the upper limit of normal), active hepatic disease, evidence of clinically significant liver disease, or other condition (eg, alcoholism, cirrhosis, or hepatitis) that suggests the potential for an increased susceptibility to hepatic toxicity with study drug exposure. 10. Subject has renal dysfunction or is at risk for renal failure due to volume depletion. 11. Subject has donated or had significant loss of whole blood (480 mL or more) within 30 days, or plasma within 14 days prior to dosing. 12. Subject has had any major surgery within 3 months prior to day-of-surgery. 13. Subject has a history of acute illness within 14 days prior to day-of-surgery. 14. Subject has participated in another clinical study within 30 days prior to day-of-surgery or plans to participate in another clinical study while concurrently enrolled in this study. 15. Subject has a history of conditions which might be specifically contraindicated or require caution to be used during the administration of any drug in the study. 16. Subject has any other medical, psychiatric and/or social reason for exclusion as determined by the investigator. 17. Subject has a positive test result for drugs of abuse (amphetamines, barbiturates, benzodiazepines, cannabinoids \[including medical use of marijuana\], cocaine, methamphetamine, methadone, or methylenedioxy-methamphetamine) at Screening. Subjects with a positive test result for prescribed drugs may be included in the study at the discretion of the investigator. Subjects with a positive test result for cannabinoids with a prescription for medical marijuana will be excluded from the study, subjects with a prescription for dronabinol (∆-9-tetrahydrocannabinol) may be included at the discretion of the investigator.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pain Intensity on a Numerical Pain Scale (NPS) for 18 Hours | 18 hours | Participants rate intensity of their pain on a Numerical Pain Scale (NPS) from 0-10, wherein 0=no pain (better) and 10=most intense pain (worse). The highest possible score is 10. |
Countries
United States
Participant flow
Participants by arm
| Arm | Count |
|---|---|
| IV Acetaminophen/Morphine IV acetaminophen 1000 mg every 6 hours over 18 hours
IV acetaminophen
Morphine: Patient controlled analgesia | 0 |
| Oral Acetaminophen/Morphine Oral acetaminophen two 500 mg tablets every 6 hours over 18 hours
Oral acetaminophen
Morphine: Patient controlled analgesia | 0 |
| Total | 0 |
Baseline characteristics
| Characteristic | — |
|---|---|
| Region of Enrollment United States | — participants |
Adverse events
| Event type | EG000 affected / at risk | EG001 affected / at risk |
|---|---|---|
| deaths Total, all-cause mortality | 0 / 0 | 0 / 1 |
| other Total, other adverse events | 0 / 0 | 1 / 1 |
| serious Total, serious adverse events | 0 / 0 | 0 / 1 |
Outcome results
Primary
Pain Intensity on a Numerical Pain Scale (NPS) for 18 Hours
Participants rate intensity of their pain on a Numerical Pain Scale (NPS) from 0-10, wherein 0=no pain (better) and 10=most intense pain (worse). The highest possible score is 10.
Time frame: 18 hours
Population: Per Protocol Analysis Set - The single participant enrolled was in violation of the protocol, leading to unreliable or uninterpretable data.