Oxytocin Effects on Likeability After Being Liked or Disliked

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02745431

Enrollment

Registered

2016-04-20

Start date

2015-06-30

Completion date

2016-06-30

Last updated

2017-08-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Social Behavior

Keywords

Likeability, Being liked

Brief summary

The current study aimed to investigate oxytocin effect on the response after the experience of being liked or disliked.

Detailed description

In a double-blind, between-subject, placebo controlled design study, the researchers aimed to investigate the intranasal OXT (40IU) treatment on rating response after being liked or disliked in healthy male subjects. All subjects completed a range of questionnaires measuring personality and affective traits and levels of anxiety: Positive and Negative Affect Schedule (PANAS) , State-Trait Anxiety Inventory (STAI) , Beck Depression Inventory (BDI), Cheek and Buss shyness Scale (CBSS),Autism Spectrum Quotient (ASQ), Empathy Quotient(EQ) before self-administration.Study participants were led to believe that other participants had formed an opinion on their likability based on their appearance in a photograph and they passively viewed the responses (like or dislike) from 'other participants'. After that, they rated 'other participants' about likeability (how much do you like the person), accuracy (have you seen the person), feeling (how good do you feel), and tendency (how much would do like have him/her as a friend). Likeability, tendency, feeling and accuracy were included into analysis as dependent variables.

Interventions

DRUGOxytocin

DRUGPlacebo

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

MALE

Age

18 Years to 30 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy subjects without past or current psychiatric or neurological disorder

Exclusion criteria

* history of head injury; * claustrophobia; * medical or psychiatric illness.

Design outcomes

Primary

Measure	Time frame	Description
Oxytocin effect on likeability after being liked or disliked	2 hour	Likeability rating was included into analysis as dependent factor.

Secondary

Measure	Time frame	Description
Relationship status may influence oxytocin effect	2 hour	subjects were subdivided into two subgroups

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026