Small Intestine Bacterial Overgrowth
Conditions
Keywords
oral vaccination, nutrition
Brief summary
The purpose of this study is to assess the impact of small intestine bacterial overgrowth (SIBO) on childhood nutritional status, growth, and oral vaccine efficacy.
Interventions
None listed
Sponsors
Virginia Commonwealth University
International Centre for Diarrhoeal Disease Research, Bangladesh
University of Virginia
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
1 Days to 7 Days
Healthy volunteers
Yes
Inclusion criteria
* Child previously enrolled in the FIELD STUDIES protocol (enrollments in both studies may occur simultaneously) * Mother willing to sign informed consent form. * Healthy infant aged less than 7 days old
Exclusion criteria
* Parents are not willing to have child's blood drawn, oral fluid collected, urine collected, or breath testing performed. * History of seizures, other apparent neurologic disorders, or other congenital abnormalities involving major organ systems.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Glucose-Hydrogen Breath Test | Birth to 2 years | Test for Small Intestine Bacterial Overgrowth |
Secondary
| Measure | Time frame |
|---|---|
| Fecal Myeloperoxidase | Birth to 2 years |
| Serum 25-OH vitamin D | Birth to 2 years |
| Serum Zinc | Birth to 2 years |
| Serum Retinol Binding Protein | Birth to 2 years |
| Serum Cobalamin | Birth to 2 years |
| Serum Albumin | Birth to 2 years |
| Fecal Regenerating Islet-Derived 1 Beta (Reg 1B) | Birth to 2 years |
| Serum Tetanus antibody titers | Birth to 2 years |
| Serum Polio antibody titers to sabin strains | Birth to 2 years |
| Oral fluid Tetanus antibody titers | Birth to 2 years |
| Height | Birth to 2 years |
| Weight | Birth to 2 years |
| Head circumference | Birth to 2 years |
| Lactulose mannitol ratio | 12 weeks of age |
Countries
Bangladesh
Outcome results
None listed