Delayed Gastric Emptying
Conditions
Keywords
delayed gastric emptying, children, monosodium glutamate
Brief summary
Children with a radionuclide gastric emptying test with abnormal results will undergo a second test with the addition of a weight adjusted dose of monosodium glutamate. The purpose of the study is to determine if a single dose of monosodium glutamate can shorten the gastric emptying time.
Detailed description
There is evidence that monosodium glutamate has effects on synapsis at the gastric and duodenum level that results in stimulation of contractility resulting on increase rate of gastric emptying. The purpose of the study is to demonstrate that the administration of a single dose of monosodium glutamate can shorten the gastric emptying time. Patients with a prior study indicating a delay of gastric empting time, will undergo a second test with the addition of a weight adjusted dose of monosodium glutamate. Each patient will serve as her/his own control. Results will be analysed by pair-T test.
Interventions
DIETARY_SUPPLEMENTMonosodium glutamate
A single dose of weight adjusted monosodium glutamate will be added at the time of a repeat radionuclide gastric emptying study
Sponsors
International Glutamate Technical Committee
Veronica Beatriz Busoni
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
12 Months to 17 Years
Healthy volunteers
No
Inclusion criteria
* children with delayed gastric emptying not receiving prokinetic medication in the last 72 hours
Exclusion criteria
* Prior gastrointestinal surgery, patients with known history of reaction to monosodium glutamate. History of neoplasia, autoimmune or inflammatory bowel disease.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Reduced gastric emptying time | During the test (4 hours from intake) | Percentage of reduction of gastric emptying time when glutamate is administered compared to baseline |
Outcome results
None listed