Diabetes, Periodontitis
Conditions
Keywords
periodontitis, diabetes, HbA1c, inflammation
Brief summary
The aim of this study is to investigate the effects of non-surgical periodontal treatment on the metabolic control of type2 diabetes patients. Patients with type two diabetes mellitus patients and confirmed chronic periodontitis will be selected and randomly assign to two groups. The treatment group will receive immediate full-mouth scaling and root planing whereas the control group will be scheduled to receive periodontal treatment at the following 3-month visit. Plaque index, bleeding index, probing pocket depth, recessions and cervical attachment loss will be recorded at baseline, at six weeks and at three months. Glycated haemoglobin (HbA1c) and C-reactive protein (CRP) will be analysed at baseline and three months following enrolment.
Detailed description
The aim of this study is to investigate the effects of non-surgical periodontal treatment on the metabolic control of type2 diabetes patients. Patients with type two diabetes mellitus patients and confirmed chronic periodontitis will be selected and randomly assign to two groups. The treatment group will receive immediate full-mouth scaling and root planing whereas the control group will be scheduled to receive periodontal treatment at the following 3-month visit. Plaque index, bleeding index, probing pocket depth, recessions and cervical attachment loss will be recorded at baseline, at six weeks and at three months. Glycated haemoglobin (HbA1c) and C-reactive protein (CRP) will be analysed at baseline and three months following enrolment.
Interventions
PROCEDUREnon-surgical periodontal treatment
full-mouth scaling and root planing
Sponsors
Yaounde Central Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Type 2 diabetes for at least one year * periodontitis * HbA1c \> 7%
Exclusion criteria
* Periodontal treatment in the last 6 months * antibiotics in the last 3 months * tobacco smoking * pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Metabolic | 3 months | Change in HbA1c |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Inflammation | 3 months | change in CRP level between baseline and 3-month post intervention |
| Periodontal 1 | 3 months | Change in plaque index between baseline and 3-month post intervention |
| Periodontal 2 | 3 months | Change in bleeding index between baseline and 3-month post intervention |
| Periodontal 3 | 3 months | Change in pocket depth between baseline and 3-month post intervention |
Countries
Cameroon
Outcome results
None listed