Chronic Endometritis, Intrauterine Adhesions
Conditions
Keywords
intrauterine adhesions, Chronic endometritis, infections, Hysteroscopy
Brief summary
This study is to evaluate the prevalence of chronic endometritis (CE) in women with severe intrauterine adhesions and compare recurrence of adhesion in women with and without CE.
Detailed description
Chronic endometritis (CE) is a persistent in endometrium that is characterized by the presence of plasma cells. Recently, there has been increasing interest in the role of CE in recurrent pregnancy loss (RPL). One of the most common uterine abnormalities for RPL is Intrauterine adhesion (IUA).Intrauterine adhesion, also known as Asherman's syndrome, is the partial or complete occlusion of the uterine cavity as a result of endometrium damage. Most intrauterine adhesions patients manifest amenorrhea, reduced menstrual pattern, infertility, and intrauterine growth restriction, which seriously affect their reproductive health.It is well established that the formation of IUA likely involves hypoxia, reduced neovascularization, and altered expression of adhesion-associated cytokines, but the exact mechanisms are not well understood. Although excessive curettage is considered the primary cause, intrauterine adhesion is known to be associated with diverse non-traumatic factors, such as postabortal sepsis, puerperal sepsis and infections. It is therefore possible to hypothesize that Intrauterine adhesion may be related to chronic endometritis. To the best of researchers knowledge,there have been no reports investigating this relationship. The aim of this study was to clarify the hypothesis by evaluating the prevalence of chronic endometritis (CE) in women with severe intrauterine adhesions and compare recurrence of adhesion in women with and without chronic endometritis (CE).
Interventions
OTHERChronic endometritis
with or without Chronic endometritis
Sponsors
First Affiliated Hospital, Sun Yat-Sen University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* Pre-operative adhesion score was ≥5 * The prior menstrual cycle was regular, and the sex hormone was normal * with informed consent * absence of other uterine abnormality at transvaginal ultrasound * There were no severe systemic diseases, and no contradictions to aspirin, estrogen and surgery.
Exclusion criteria
* Pre-operative adhesion score was \<5 * Prior menstrual cycle was irregular and sex hormone was abnormal, or patients had endocrine factors that caused amenorrhea, menstrual reduction and infertility * other uterine abnormality at transvaginal ultrasound * without informed consent * Patients had contradictions to estrogen and aspirin such as cancers (breast cancer and endometrial cancer), thrombotic diseases, allergy to antipyretic analgesics, severe liver injury, hypoprothrombinemia, vitamin K deficiency, hemophilia, thrombocytopenia, gastric or duodenal ulcer and asthma * refuse Endometrial biopsy * Vaginal discharge abnormal, or Suspected vaginitis or pelvic inflammatory disease, or using antibiotics.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of Participants With recurrence of adhesion in women with and without Chronic endometritis | 1 year | Second-look hysteroscopy was carried out in the early proliferative phase, 1 to 3 months after the initial operation.After assessment of the extent and severity of any reformed adhesions, hysteroscopic adhesiolysis was also carried out at the time of the second-look procedure, if adhesions had recurred. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Reduction of American Fertility Society adhesion score at Second-look hysteroscopy between women with and without Chronic endometritis | 1 year | The severity and extent of intrauterine adhesions were scored according to a classification system recommended by the American Fertility Society (AFS) (1988 version) \[7\]. A score of 1-4 was considered to represent mild adhesions, a score of 5-8 was considered to represent moderate adhesions and a score of 9-12 represented severe adhesions. |
| Number of patients diagnosed with Chronic endometritis at hysteroscopy | 1 year | Chronic endometritis signs at hysteroscopy included \[1\] pedunculated and vascularized micro-polyps (\<1 mm), most frequently found near the endocervical area (2); and \[2\] the presence of areas of hyperemic endometrium flushed with a white central point, localized or scattered throughout the cavity, referred to as strawberry aspect. |
| Number of patients with Chronic endometritis confirmed by histology | 1 year | Endometrial samples were fixed in neutral formalin and later embedded in paraffin for histological analysis. Five-micrometer sections were stained with hematoxilin-eosin. Histological diagnosis of Chronic endometritis: Attention was paid to the following features: superficial stromal edema, increased stromal density, pleomorphic stromal inflammatory infiltrate dominated by lymphocytes and plasma cells. |
Outcome results
None listed