Cerebral Perfusion Pressure, Magnetic Resonance Imaging (MRI), Functional, Shock, Vasopressor Agents
Conditions
Brief summary
The aim of the study is to measure cerebral perfusion using MRI in healthy subjects (with and without sedation) and in vasopressor-dependent patients
Interventions
DRUGHigher doses of vasopressor therapy for a MAP of 75 mmHg
DRUGLower doses of vasopressor therapy for a MAP of 65 mmHg
DRUGPropofol for light sedation
Propofol for light sedation
Sponsors
Centre de recherche du Centre hospitalier universitaire de Sherbrooke
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
SUPPORTIVE_CARE
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
Healthy Subjects : * Inclusion criteria : * being over 18 years old *
Exclusion criteria
s : * having a positive serum pregnancy test * having a contraindication to MRI * having a contraindication to receive light sedation with propofol * suffering of claustrophobia or of anxiety disorder Shock Subjects : * Inclusion criterias : * being over 18 years old * being hospitalized to the medical intensive care unit of the CHUS Fleurimont * being in a stabilized shock state, primarily of distributive etiology * having received an appropriate fluid resuscitation, as judged by the attending physician *
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Global and regional cerebral blood flow | Within 15 minutes of intervention initiation | Cerebral blood flow will be measured by the arterial spin labeling technique (ASL) which provides information expressed in mL/100g/min. Using 3-T MRI technology,we will first acquire T1 images of the brain and sub-regions of interest. Thereafter, ASL sequences will be acquired in contiguous slices. The procedure will be followed on sedation and off sedation for healthy volunteers (in random order) and at mean arterial pressure of 65 mmHg and 75 mmHg (in random order) in patients receiving vasopressor therapy. |
Countries
Canada
Outcome results
None listed