Comparison of Palonosetron Versus Combination of Palonosetron and Dexamethasone for Preventing Postoperative Vomiting in Patients Receiving Fentanyl by Patient-controlled Analgesia After Minor Orthopedic Surgery

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02744508

Enrollment

202

Registered

2016-04-20

Start date

2015-07-24

Completion date

2017-03-20

Last updated

2018-06-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Orthopedic Surgery

Keywords

palonosetron, dexamethasone, PONV (postoperative nausea and vomiting)

Brief summary

Postoperative nausea and vomiting (PONV) is related with extended hospital day and risk factor of aspiration pneumonia. Postoperative patient controlled intravenous analgesia is related with postoperative nausea and vomiting. Selective 5-HT3 antagonist, Palonosetron, is the most recent medication for prevention of PONV. Purpose of our study is comparison of PONV preventive effect of palonosetron and combination of palonosetron and dexamethasone.

Interventions

DRUGpalonosetron

DRUGpalonosetron with dexamethasone

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

20 Years to 65 Years

Healthy volunteers

Inclusion criteria

* patients who are undergoing minor orthopedic surgery. * IV patient controlled analgesia

Exclusion criteria

* 1\. minority (0\ 19 year) * patients who are belongs to ASA class 3 or more, and have underlying complicated cardiovascular or psychological disease. * Steroid medication * Diabetes Mellitus medication

Design outcomes

Primary

Measure	Time frame
incidence of clinically significant PONV with PONV impact scale	72 hours

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026