Food and the Brain

Emotion and Reward Processing in Binge Eating

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02743000

Enrollment

Registered

2016-04-19

Start date

2016-01-31

Completion date

2020-04-30

Last updated

2020-10-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Binge Eating

Keywords

fMRI, emotion conflict task, monetary incentive delay

Brief summary

The proposed study will examine the role of reward and emotion in women with and without a history of binge eating. It is important to understand how the brain responds to reward and emotion in binge eating in order to identify different pathways toward binge eating and provide individualized targets for treatment. This is particularly important in light of the fact that for many patients, the current treatments for binge eating are not effective.

Interventions

None listed

Study design

Observational model

ECOLOGIC_OR_COMMUNITY

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 35 Years

Healthy volunteers

Yes

Inclusion criteria

* Female * Ages 18-35 * with or without current binge eating behaviors

Exclusion criteria

* Any contraindication for MRI (orthodontia, vascular stents, metallic ear tubes, metal implants, piercings, etc). * substance abuse * traumatic brain injury * BMI \< 18.5 * pregnant women

Design outcomes

Primary

Measure	Time frame	Description
Brain activity during rest	Baseline	Functional magnetic resonance imaging will be used to measure brain activity at rest and connectivity between brain regions will be examined.
Brain activity during emotion conflict	Baseline	Functional magnetic resonance imaging will be used to measure brain activity during a task where participants respond to images of faces with emotional expressions overlaid with an emotion word written in text. We will focus on brain response during this task when emotion face vs word are in conflict.
Brain activity during monetary wins and losses	Baseline	Functional magnetic resonance imaging will be used to measure brain activity during a game where participants can win or lose money if they respond to a shape on the computer screen. Brain response during wins and losses will be examined.

Countries

United States

Outcome results