Microcephaly
Conditions
Keywords
Microcephaly, zika Virus, Case-control study
Brief summary
It is suspected that zika virus infection during pregnancy is associated with microcephaly. The objective of this study is to investigate the occurrence of rash accompanied by three or more dengue-like signs and symptoms during pregnancy is related to the microcephaly using the case-control design.
Detailed description
The investigators will carry out a case-control study among mothers who delivered their babies at Nossa Senhora de Lourdes maternity hospital located in Aracaju, state of Sergipe, Brazil from September 1, 2015 through January 5, 2016. Data sources for the phase I of the study will consist of medical records review and a standard questionnaire applied by telephone to collect information about demographic features, clinical signs and symptoms, and the duration and severity of the illness. Phase II will include dengue, chikungunya and dengue serologic test results as secondary outcome, if available. The objective of this study is to investigate the occurrence of rash accompanied by three or more dengue-like signs and symptoms during pregnancy is related to the microcephaly using the case-control design
Interventions
OTHERQuestionary
Questionary with clinical, demographic and behavior outcomes at the pregnancy period
Sponsors
Laboratório Sabin
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
16 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Delivered a baby at nossa senhora de lourdes maternity from September 1, 2015 through january 5, 2016.
Exclusion criteria
* Syphilis during pregnancy, toxoplasmosis during pregnancy, consanguinity, other genetics disorder, alcohol or abuse drug consumption during pregnancy.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Zika virus infection clinical outcomes during pregnancy | From September 1, 2015 through January 5, 2016 | acute onset of generalized rash together with three of the following symptoms: Conjunctivitis, arthralgia, mild-fever or periarticular edema. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| zika virus serology | march, 2016 through July 5, 2016 | If available, zika virus serology will be performed |
| Chikungunya virus serology | march, 2016 through July 5, 2016 | If available, chikungunya virus serology will be performed |
| Dengue virus serology | march, 2016 through July 5, 2016 | If available, Dengue virus serology will be performed |
Countries
Brazil
Outcome results
None listed