Cardiac Arrythmias
Conditions
Brief summary
The primary purpose of this study is to improve the quality of Magnetic Resonance Imaging in patients with heart arrhythmia. Investigators will recruit 105 patients with arrhythmia and 30 control volunteers over 3 years and will use two arrhythmia-tolerant imaging methods for diagnosis.
Detailed description
In the proposed research, investigators will extend conventional cardiac magnetic resonance methods to enable the creation of high-quality cine CMR images in the presence of multiple kinds of arrhythmia. Two arrhythmia-tolerant imaging methods will be adopted, which are particularly useful in arrhythmia: 1) 3D imaging, which is useful for many purposes, including "road mapping" of electrophysiology (EP) procedures, and 2) late gadolinium enhancement (LGE), which is useful for delineating abnormal myocardium, including fibrotic regions that can serve as sources of arrhythmias.
Interventions
OTHER3D Imaging
"roadmapping" of electrophysiology (EP) procedures
OTHERLate Gadolinium Enhancement (LGE)
useful for delineating abnormal myocardium, including fibrotic regions that can serve as sources of arrhythmias.
Sponsors
NYU Langone Health
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
10 Years to 85 Years
Healthy volunteers
Yes
Inclusion criteria
for Arrhythmia Patients: * Patients diagnosed with heart arrhythmia scheduled for routine clinical MRI examinations). * Patients scheduled for routine clinical MRI examinations who do not have a specific known diagnosis of arrhythmia, but who may be found to have image degradation due to arrhythmia during the CMR examination. Inclusion Criteria for Controls: * No history of heart arrhythmia.
Exclusion criteria
for Patients and Controls: * Hemodynamic instability. * Contraindications for MRI examinations (e.g., pacemakers or ferromagnetic vascular clips). * History of prior cardiovascular disease or significant risk factors: * Diabetes, hypertension, smoking, and hyperlipidemia, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Paired-sample Wilcoxon signed rank test to evaluate measures on Likert scales | 3 Years |
| Paired-sample t tests for quantitative measures of intensity of image artifacts | 3 Years |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORLeon Axel, MD
New York University Medical School
Outcome results
None listed