E-cigarettes and Blood Vessel Function

The Effects of Electronic Cigarettes on Endothelial Function and Oxidative Stress

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02740595

Enrollment

148

Registered

2016-04-15

Start date

2015-08-31

Completion date

2022-12-01

Last updated

2023-10-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nicotine Dependence

Keywords

nicotine, endothelial function, oxidative stress

Brief summary

Randomized controlled trial of electronic cigarettes with nicotine, without nicotine, and sham control, on endothelial function and markers of oxidative stress.

Detailed description

Participants will use an electronic cigarette on 3 occasions: 1) with nicotine, 2) without nicotine, 3) sham control, and undergo a measure of endothelial function called brachial artery flow mediated dilatation (FMD). Additionally, oxidative stress will be measured pre and post exposure.

Interventions

OTHERone time exposure to e-cig with nicotine

one time exposure to e-cig vapor with nicotine

OTHERone time exposure to e-cig without nicotine

one time exposure to e-cig without nicotine

OTHERone time exposure to empty e-cig

one time exposure to empty e-cig (sham control

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

21 Years to 45 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy

Exclusion criteria

* Cardiac disease * Respiratory disease * Diabetes mellitus

Design outcomes

Primary

Measure	Time frame	Description
Flow mediated dilatation (FMD)	10 minutes after exposure	FMD is a measure of endothelial function
Paraoxonse	less than 1 hour after exposure	plasma oxidative stress

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026