Communicable Diseases
Conditions
Keywords
chronic coinfection
Brief summary
This observational epidemiologic study with nested cross-sectional and longitudinal aims will evaluate host immune response to mixed chronic infections (Helicobacter pylori, latent tuberculosis, intestinal helminthiasis) in recent US immigrants.
Detailed description
1750 clinically-well, adult (age 18-55 years), recent immigrants (\<2 years U.S. residence), referred through cooperating public health clinics in the Santa Clara Valley area, CA will be screened for H. pylori, helminth, and latent tuberculosis infections \[Screening population\]. Of these 1750, 426 will be selected for more intensive study (Cohort population), 105 of whom will receive baseline endoscopy. Of those selected for the cohort, 300 are expected to complete a 9-month follow-up assessment, 75 of whom are expected to undergo a second follow-up endoscopy.
Interventions
None listed
Sponsors
Santa Clara Valley Health & Hospital System
Stanford University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* Between 18-55 years of age * Either sex * If female not pregnant or breastfeeding * Lived in the United States less than 2 years * Healthy * Scheduled for Tuberculosis Skin Test (TST)
Exclusion criteria
* Under 18 and older than 55 years of age, * Pregnant or breastfeeding * Have lived in Unites States more that 2 years * Chronic illness * Not planning to get a TST
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in cytokine responses from baseline at 9 months in TB and H. pylori antigen-induced PBMC before and after provider managed treatment of latent TB or helminth infection | Baseline and 9 months after treatment for either latent TB or helminth infections; analyzed after all subjects recruited (3 years of recruitment plus 9 months follow-up). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Correlation of cytokine response to TB antigens and helminths with humoral responses to infections with H. pylori. | Assays performed when collected over three years from recruited subjects; analyzed at the end of three years. | — |
| Population prevalence of individual and joint infections with H pylori, latent tuberculosis, heminthiasis in recent immigrant to northern California | Assays performed when collected over three years from recruited subjects; analyzed at the end of three years. | We compare prevalence of these infections in recent immigrants by geographic area |
Countries
United States
Outcome results
None listed