Chronic Periodontitis With Mandibular Degree 2 Furcation Defects
Conditions
Brief summary
The purpose of this double-masked, randomized, controlled clinical trial was to evaluate the effects of subgingival delivery of boric acid gel as an adjunct to scaling and root planing (SRP) on clinical and radiographic parameters and compare this method with SRP plus placebo gel alone in patients with chronic periodontitis (CP).
Detailed description
Background: The purpose of this double-masked, randomized, controlled clinical trial was to evaluate the effects of subgingival delivery of boric acid gel as an adjunct to scaling and root planing (SRP) on clinical and radiographic parameters and compare this method with SRP plus placebo gel alone in patients with chronic periodontitis (CP). Methods:FORTY EIGHT systemically healthy patients with CP are included in this study. They were divided into two groups: 1) SRP + 0.75% Boric acid gel (BA group); 2) SRP + Placebo gel (Placebo group). At baseline, 3 month, and 6 months after treatment, clinical measurements, including plaque index (PI), modified sulcus bleeding index (mSBI), probing depth (PD), clinical attachment level (CAL) and radiographic parameters intrabony defect depth (IBD), percentage change in radiographic defect depth reduction (DDR%) were assessed.
Interventions
DRUG0.75 % Boric Acid
After Scaling and Root Planing placement of 0.75% Boric Acid gel in Mandibular degree 2 Furcation defect.
DRUGplacebo
After Scaling and Root Planing placement of Placebo gel in Mandibular degree 2 Furcation defect.
Sponsors
Government Dental College and Research Institute, Bangalore
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
30 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* Presence of buccal Class II furcation defects in endodontically vital, asymptomatic mandibular first and second molars with a radiolucency in the furcation area on an intraoral periapical radiograph with probing depth (PD) ≥ 5mm and horizontal ≥ PD 3mm after phase I therapy i.e, scaling and root planing (SRP) * No history of antibiotic or periodontal therapy in the preceding 6 months
Exclusion criteria
* Systemic conditions known to affect the periodontal status * Medications known to affect the outcomes of periodontal therapy * Hematological disorders and insufficient platelet count (\<200,000/mm3) * Pregnancy/lactation * Smoking and tobacco use in any form * Immunocompromised individuals * Those having unacceptable oral hygiene (plaque index \[PI\] \>1.5) * Teeth with furcation involvement, non-vital teeth, and carious teeth indicated for restorations and mobility of at least grade II * Aggressive periodontitis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Radiographic bone fill | Baseline to 6 months | assessed in percentage |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| probing depth | 3 and 6 months | measured in mm |
| Relative vertical attachment leve | 3 and 6 months | measured in mm |
| Relative horizontal attachment level | 3 and 6 months | measured in mm |
| modified sulcus bleeding index | 3 and 6 months | 0-3 scale |
| plaque index | 3 and 6 months | 0-3 scale |
Countries
India
Outcome results
None listed