Hypertension
Conditions
Keywords
Hypertension, Cognition, Computerized Training, Cogmed
Brief summary
Systemic arterial hypertension is a disease with high prevalence in several countries, including Brazil. Many studies have correlated hypertension with accelerated loss of cognitive function, especially executive functions. There is some evidence that working memory (WM) is compromised in these populations. However, some computerized training has been developed to rehabilitate the WM, and among them the investigators highlight the Cogmed. Thus, the aim of this study is to evaluate the effects of Cogmed training in the performance of WM and attention of hypertensive patients, as well as the impact of training in the structure and brain function.
Interventions
OTHERCogmed
The Cogmed is computer software designed to train visuospatial and audio-verbal working memory, and other functions associated with working memory: attention, focus and impulsiveness. It has three versions adapted to different age groups: Cogmed for younger children, about 4-7 years, which are not yet so familiar with numbers and letters; Cogmed for children over 7 years and adolescents; and Cogmed for youth and adults over 18 years. In this study we will use the version for youth and adults over 18 years.
Sponsors
University of Sao Paulo General Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
40 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Individuals of both genders, of any ethnicity * Signing the consent form * Access to computer with internet at home * Inexperienced to computerized cognitive training * Hypertensive pre-diagnosed * Basic schooling of four years * Cognitive impairment
Exclusion criteria
* Marked functional limitation * Cognitive limitation or serious communication * Severe neurological and psychiatric diseases * Stroke history, head trauma or substance abuse
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Working memory score | 10 weeks | Backward Digits Test / Letter-Number Sequencing (WAIS-III): total score (sum of right answers) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Brain function | 10 weeks | Functional magnetic resonance |
| Executive functions score | 10 weeks | Stroop test, Wisconsin Card Sorting Test, Frontal Assessment Battery and Controlled Oral Word Association Test |
| Verbal memory score | 10 weeks | Stories of Wechsler Memory Scale Revised - WMS R |
| Visual memory score | 10 weeks | Rey complex figure |
Other
| Measure | Time frame | Description |
|---|---|---|
| Quality of life score | 10 weeks | Whoqol |
| Perceived Stress score | 10 weeks | PSS14 |
| Anxiety and Depression symptoms score | 10 weeks | BAI and BDI questionnaires |
| Medication adherence score | 10 weeks | Short version of Morinsk Questionnaire |
Countries
Brazil
Outcome results
None listed