Atrial Fibrillation, Coronary Artery Bypass Grafting, Obstructive Sleep Apnea
Conditions
Brief summary
Background. Atrial fibrillation is one of the most common complications in the postoperative period of coronary artery bypass grafting (CABG) surgery and usually associated with increased length of hospital stay and higher hospital costs. Among the main mechanisms involved, excessive sympathetic activation, oxidative stress and inflammation are fundamental elements in the pathophysiology of obstructive sleep apnea. Objectives. To evaluate the effects of continuous positive airway pressure (CPAP) in reduction of atrial fibrillation after CABG in patients with obstructive sleep apnea. Methodological procedures: A multicenter randomized controlled study to compare the incidence of atrial fibrillation between the intervention group and the control group, both monitored seven days with Holter.
Interventions
DEVICECPAP
patients will receive CPAP therapy with Auto-CPAP
Sponsors
Rodrigo Pinto Pedrosa
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
30 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* apnea-hypopnea index \> 15 events/hour
Exclusion criteria
* ejection fraction \< 45% * chronic atrial fibrillation * periprocedural instability (haemodynamic, neurological)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| atrial fibrillation | first 7 days after CABG | will be verified by holter monitoring |
Countries
Brazil
Outcome results
None listed