Sarcoidosis, Fatigue
Conditions
Keywords
Sarcoidosis, Fatigue, Exercise
Brief summary
The aims of the current study is to explore if different exercise training protocols affect fatigue post-exercise, and if sarcoidosis-related fatigue and maximal and sub-maximal cardiopulmonary exercise test (CPET) variables change after a 4-weeks exercise training period.
Detailed description
This project aims to provide data on post-exercise fatigue after single exercise sessions with endurance training and muscle strength training, each with two different intensities. For endurance training; post-exercise fatigue will be assessed after one session of high intensity interval training, and one session with longer duration of moderate intensity. For muscle strength training, fatigue will be measured after one session with high loads/few repetitions and one session with low loads/many repetitions. In addition, changes in sub-maximal and maximal metabolic and ventilatory responses to a maximal cardiopulmonary exercise test on a treadmill (CPET) and association to sarcoidosis-related fatigue before and after a 4-weeks exercise training period will be studied.
Interventions
Two different muscle strength training protocols will be compared; one exercise session with high load/low repetitions (4 sets x 5RM) versus one exercise session with low load/high repetitions (2 sets x 25RM). Both session will be conducted at four different exercises; seated leg press, chest press, cable lat pull down and seated rowing.
Two different endurance exercise training protocols will be compared; one exercise sessions is interval training with high intensity (85-95% of HRmax) versus one of moderate intensity (70-75% of HRmax) with longer duration.
Sponsors
University of Oslo
Hasselt University
LHL Helse
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Patients with sarcoidosis diagnosed according to the latest American Thoracic Society/European Respiratory Society/World Association for Sarcoidosis and Other Granulomatous Disorders (ATS/ERS/WASOG) statement on sarcoidosis who are attending a four weeks exercise based pulmonary rehabilitation program at LHL-klinikkene Glittre.
Exclusion criteria
* Patients with a concurrent and predominant diagnosis of another significant respiratory disorder (for example: asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis, or lung cancer). * Unstable cardiovascular disease. * Not able to perform the required physical tests and exercise training sessions caused by co-morbidities.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in fatigue | Fatigue measured immediately before and acute after exercise sessions, (within 1 min.), and addition 24 hours post-exercise. | Changes of fatigue will be assessed assessed by Visual Analogue Scale (VAS), where the grade of fatigue is assessed between 0 (no fatigue) and 10 (maximal fatigue). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in blood lactate | Blood lactate are measured before and acute after exercise sessions (within 2 min.), and in addition 24 hours post-exercise. | Blood lactate will be assessed by capillary puncture in a finger tip. |
| Change in sarcoidosis related fatigue | Measured first day and last day of a 4-week exercise based pulmonary rehabilitation | Assessed by the Fatigue Assessment Scale (FAS) |
| Change in metabolic and ventilatory variables from CPET | Measured during a CPET first day and last day of a 4-week exercise based pulmonary rehabilitation | Ratio ventilation/carbon dioxide output (VE/VCO2) |
| Change in maximal oxygen uptake | Measured during a CPET first day and last day of a 4-week exercise based pulmonary rehabilitation | Maximal oxygen uptake (VO2, mL/min) |
Countries
Norway
Outcome results
None listed