Comparing Cardiovascular Effects of 1:100,000 and 1:200,000 Epinephrine Solutions

Randomized Double-blind Clinical Trial Comparing the Cardiovascular Effects of Local Anesthesia Solutions Containing 1:100,000 and 1:200,000 of Epinephrine Concentrations

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02735018

Enrollment

Registered

2016-04-12

Start date

2014-12-31

Completion date

2015-03-31

Last updated

2016-04-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiovascular Response to Epinephrine

Brief summary

The study aim to evaluate systemic response of patients when 2 different concentrations of Epinephrine are injected during inferior alveolar nerve block for wisdom teeth extraction.

Interventions

DRUGEpinephrine 1:100,000

Inferior alveolar nerve block with Epinephrine 1:100.000

DRUGEpinephrine 1:200,000

Inferior alveolar nerve block with Epinephrine 1:200.000

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Caregiver)

Eligibility

Sex/Gender

ALL

Age

13 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

* Class I patients according to the American Society of Anesthesiology (ASA), * Indication for third molars extraction, * Similar degree of complexity, according to the classification of Pell and Gregory.

Exclusion criteria

* Patients with systemic conditions, * Patients with known allergy to any component of the anesthetic solution.

Design outcomes

Primary

Measure	Time frame
Heart rate	20 minutes
Blood pressure	20 minutes
Arterial oxygen saturation, measured with a pulse oximeter device	20 minutes
Bleeding, evaluated by the surgeon as either: 1) normal or 2) excessive	20 minutes
Pain, evaluated using a visual analogue scale	After procedure, about 1 hour

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026