Collagen Alterations in Patients With Abdominal Wall Hernias

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02734563

Enrollment

174

Registered

2016-04-12

Start date

2011-01-31

Completion date

2014-12-31

Last updated

2017-07-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hernia, Abdominal

Brief summary

The aim of this study was to evaluate collagen turnover in patients with multiple hernias

Detailed description

Venous blood was collected and markers for type IV and V collagen synthesis and breakdown was measured

Interventions

OTHERCollagen turnover

Type IV and V collagen synthesis and breakdown

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

MALE

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* patients with a history of three hernia repairs (multiple hernia group) * patients without any history or presence of hernias (control group)

Exclusion criteria

* connective tissue disorder (Ehlers-Danloss/Marfan) * presence of hernia upon clinical examination (control group)

Design outcomes

Primary

Measure	Time frame	Description
Type IV and V collagen synthesis and breakdown	3 months	Products from type IV and V collagen synthesis and breakdown are measured in serum. with ELISA from Nordic Bioscience A/S, Herlev, Denmark. Specifically, the biomarker for type IV collagen synthesis (P4NP) and breakdown (C4M), and for type V collagen synthesis (P5CP) and breakdown (C5M) was measured. The concentration unit for all parameters is ng/ml.

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026