Histones and Free-plasma DNA After Cardiac Arrest

Histones and Free-plasma DNA in the Days Following the Cardiac Arrest

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02733146

Enrollment

Registered

2016-04-11

Start date

2015-10-31

Completion date

2016-09-30

Last updated

2017-06-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart Arrest, Hypothermia, Post Cardiac Arrest Syndrome

Brief summary

To evaluate the significance of free-plasma deoxyribonucleic acid (DNA) and plasma histones in cardiac arrest patients.

Interventions

OTHERcardiac arrest

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

* Out of hospital cardiac arrest of presumed cardiac cause * Return of spontaneous circulation (ROSC) * Glasgow Coma Score \< 8 * Age \> 18 years and \< 80 years

Exclusion criteria

* \>60 minutes from the circulatory collapse to ROSC * Time interval \> 4 hours from cardiac arrest to initiation of targeted temperature management * Terminal illness * Coagulation disorder * Unwitnessed asystolia * Cerebral performance category 3-4 before the cardiac arrest * Severe persistent cardiogenic shock * Pregnancy * Persistent cardiogenic shock (systolic blood pressure \< 80 despite inotropic treatment) * New apoplexy or intracerebral hemorrhage * Lack of consent from the relatives * Lack of consent from the general practitioner * Lack of consent from the patient if he/she wakes up and is relevant

Design outcomes

Primary

Measure	Time frame	Description
Plasma histones	Approximate 24 hours after cardiac arrest	The level of plasma histones
Free-plasma DNA	Approximate 24 hours after cardiac arrest	The level of total free-plasma DNA

Secondary

Measure	Time frame	Description
Plasma histones	Approximate 48 hours and 72 hours after cardiac arrest	The level of plasma histones
Free-plasma DNA	Approximate 48 hours and 72 hours after cardiac arrest	The level of total free plasma DNA

Other

Measure	Time frame
Simplified Acute Physiology Score (SAPS) score	Approximate 24 hours, 48 hours and 72 hours after cardiac arrest
Platelet count	Approximate 24 hours, 48 hours and 72 hours after cardiac arrest

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026