Metabolic Syndrome
Conditions
Brief summary
The purpose of this study is to determine how chronic inflammation influences skeletal muscle protein metabolism and metabolic function in humans. The investigators will evaluate acute responsiveness to a single bout of exercise in men and women who are either lean or overweight/obese. The investigators will explore the relationship between circulating inflammatory markers and anabolic, proteomic, and transcriptional responses to acute exercise. The investigators will measure skeletal muscle protein synthesis in the postabsorptive state and in response to a single bout of exercise.
Interventions
None listed
Sponsors
Mayo Clinic
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
30 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* Age 30-55 years * BMI 19-45 kg/m2
Exclusion criteria
* Anemia (female subjects hemoglobin of \<11 g/dl and male subjects hemoglobin \<12 g/dl) * Active coronary artery disease or history of unstable macrovascular disease (unstable angina, myocardial infarction, stroke, and revascularization of coronary, peripheral or carotid artery within 3 months of recruitment) * Renal insufficiency/failure (serum creatinine \> 1.5mg/dl) * Oral warfarin group medications or history of blood clotting disorders. * Pregnancy or breastfeeding * Alcohol consumption greater than 2 glasses/day or other substance abuse * Untreated or uncontrolled thyroid disorders * Debilitating chronic disease (at the discretion of the investigators)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Maximal oxygen consumption rates in mitochondria isolated from skeletal muscles | 1 day |
Countries
United States
Outcome results
None listed