Respiratory Distress Syndrome, Adult, Ventilator-Induced Lung Injury
Conditions
Brief summary
Asynchrony during mechanical ventilation has been poorly described in patients suffering from acute respiratory distress syndrome. The purpose of this study is to describe the frequency of asynchronies (ineffective efforts and double triggering) in these group and evaluate potential risk factors and prognosis implications.
Detailed description
Major patient-ventilator asynchronies have been described during assisted mechanical ventilation in different settings. Few studies have evaluated double cycling in ARDS patient. No clear predictors of this finding beside low tidal volume have been found, and clinical outcome implications have not been addressed. This study has 3 main objectives: evaluate the frequency of double cycling and ineffective efforts, seek for potential predictors and clinical outcomes related to asynchronies. Subjects with less than 72 hours of mechanical ventilation due to ARDS will be recruited. Thirty minutes of mechanical ventilation will be recorded and automatically analyzed with a custom-made program to detect asynchronies. A blood sample will be drawn to measure inflammatory and lung tissue damage biomarkers. Clinical and outcome data will be recorded.
Interventions
None listed
Sponsors
Centro de Educación Medica e Investigaciones Clínicas Norberto Quirno
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 100 Years
Healthy volunteers
No
Inclusion criteria
* Acute Respiratory Distress Syndrome according to Berlin definition * Intubation and mechanical ventilation within 72 hours of inclusion
Exclusion criteria
* Known severe neuromuscular disease * Continuous neuromuscular blocking agents infusion
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Asynchrony rate | 30 minutes | Asynchronies per minutes of mechanical ventilation |
Secondary
| Measure | Time frame |
|---|---|
| Length of mechanical ventilation | From the date of intubation to the date of complete weaning from mechanical ventilation or death which ever comes first, up to 90 days |
| ICU mortality | From the date of admission to the date of discharge from the ICU, up to 90 days |
| Hospital mortality | From the date of admission to the date of discharge from the ICU, up to 90 days |
Countries
Argentina
Outcome results
None listed