Postoperative Pain
Conditions
Brief summary
this study compares the use of intrathecal morphine, to multimodal analgesic techniques for postoperative pain management following laparoscopic bariatric surgery.
Interventions
DRUGintrathecal morphine
received 0.3mg morphine (0.3ml) added to 1.2ml of bupivacaine 0.5% (total volume 1.5ml), intrathecally, immediately before induction of general anesthesia.
received 0.3ml saline added to 1.2mlof bupivacaine 0.5% (total volume 1.5ml), intrathecally, immediately before induction of general anesthesia.
Sponsors
Assiut University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
20 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
* American Society of Anesthesia (ASA) II-III patients. * Aged 30-50 years. * The body mass index (BMI) of the patients needed to be over 40 kg/m² or over 35 kg/m² with at least one comorbidity.
Exclusion criteria
* Patients with a known allergy to the study drugs. * Advanced cardiac, respiratory, renal or hepatic disease. * Coagulation disorders. * Infection at or near the site of intrathecal injection. * Drug or alcohol abuse. * Psychiatric illnesses that may interfere with perception and assessment of pain.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Total postoperative analgesic consumption. | 24 hours postoperative | the efficacy of the studied dose of intrathecal morphine in reducing postoperative analgesic consumption. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Visual analogue scale (VAS) scores | 24 hours postoperative | postoperative pain scores |
| Time to first request of rescue analgesia. | 24 hours postoperative | — |
| Tolerability as assessed by the incidence of side effects | 24 hours postoperative | the incidence of side effects |
Outcome results
None listed