Chronic Intestinal Pseudo Obstruction
Conditions
Keywords
Fecal Microbiota Transplantation, Chronic intestinal pseudo obstruction, Efficacy and safety
Brief summary
Chronic intestinal pseudo obstruction(CIPO) is a serious motility disorder with life-threatening condition, and it is often related with bacterial overgrowth. Fecal microbiota transplantation (FMT) results in restoration of the normal intestinal microbial community structure. The investigators planned to observe the efficacy of FMT in the treatment of a series CIPO patients. Patients received FMT on 6 consecutive days through nasojejunal tubes and followed up for 8 weeks after treatment. Rate of clinical improvement and remission, feeding tolerance of enteral nutrition, CT score of intestinal obstruction, and gastrointestinal quality-of-life index(GIQLI) were evaluated.
Interventions
PROCEDUREfecal microbiota transplantation
Patients received frozen FMT on 6 consecutive days through nasojejunal tubes.
Sponsors
Jinling Hospital, China
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Patients had to have a firm diagnosis diagnostic criteria for CIPO proposed by Ministry of Health, Labour, and Welfare, including documented pathological bowel dilatation on imaging in the absence of mechanical obstruction.
Exclusion criteria
None.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| the tolerance of enteral nutrition (EN) through nasojejunal tube | 8 weeks | We defined feeding intolerance (FI) as inability to deliver the amount of nutrient as a proportion of 'energy requirements', with values of 80% chosen, or a certain amount (750ml) per 24h. |
| the time oral intake started | 8 weeks | The time when oral intake (both fluids and solid food) started was noted. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| symptomatic relief | 8 weeks | The occurrence and severity of each of these symptoms: pain, nausea, vomiting and bloating (each scored as 0 = absent, 1 = mild, 2 = medium, 3 = severe, or 4 = could not be worse) were recorded by nurses blinded to the intervention on a daily basis. |
| scoring evaluation of abdominal CT | 8 weeks | We use a computed tomography scoring system to evaluate the severity of obstruction. |
Countries
China
Outcome results
None listed