Colon Cancer
Conditions
Brief summary
This is a study whose focus is on understanding the clinical utility of rectal ultrastructure in detecting colonic neoplasm. The method uses Low-coherence Enhanced Backscattering Spectroscopy (LEBS).
Detailed description
The investigators use an optic probe which is a small device that uses light to assess the colon tissue. This probe will be used to identify subjects who do and do not have precancerous changes in the colon by capturing the light reflected back from the rectal wall and that will be assessed without the need for colonoscopy and bowel preparation (i.e unprepped). This device may detect early cancerous changes in colon tissue with higher accuracy than current tests.
Interventions
DEVICELEBS - Low coherence enhanced backscattering
Unprepped patients will have the LEBS probe brought into contact with the rectal mucosa, upon which 10 random readings will be obtained.
Sponsors
American BioOptics, LLC
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
50 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
\- Subjects are eligible if they were scheduled for colonoscopy for colon cancer screening or surveillance
Exclusion criteria
* age \<50 * personal/family history of colonic neoplasia * personal history of coagulopathy * (retrospectively) failure to complete or inadequate colonoscopy * any patients harboring non-pathoglocially normal rectum (i.e. presence of lesion, inflammation, polyp, adenomas at rectum)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Whether rectal LEBS readings can predict the presence of advanced adenomas in the colon. | Through study completion, an average of 1 year |
Countries
United States
Outcome results
None listed