Preoperative Ketorolac for Pain Control in Scleral Buckle Surgery

Preoperative Ketorolac for Intraoperative and Postoperative Pain Management in Scleral Buckling Surgery Under Retrobulbar Block Anesthesia: A Prospective, Randomized, Controlled Study

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02729285

Enrollment

Registered

2016-04-06

Start date

2014-07-31

Completion date

2014-10-31

Last updated

2016-09-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain

Brief summary

The scleral buckle surgery is an effective way in treating retinal detachment (RD) patients. Retrobulbar block has been proved effective in scleral buckle surgery. Though retrobulbar anesthesia saves operative time and money compared to general analgesia, the intraoperative pain is frequent and a proportion of postoperative pain is often ignored. Ketorolac has been demonstrated to be a preemptive analgesia in other diseases such as adenotonsillectomy, posterior lumbar spinal fusion, laser-assisted subepithelial keratectomy (LASEK), and so forth. The aim of the investigators study is to determine the safety and preemptive analgesic effect of ketorolac in the perioperative pain control of patients undergoing RD surgery under retrobulbar anesthesia.

Interventions

DRUGKetorolac Tromethamine

On operation day, the patients were randomly assigned to receive intramuscular Ketorolac 60-mg 30 min before scleral buckle surgery.

DRUGplacebo

On operation day, the patients were randomly assigned to receive placebo 30 min before scleral buckle surgery.

PROCEDUREscleral buckle

Surgical procedure of scleral buckle under retrobulbar block anesthesia

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SUPPORTIVE_CARE

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

1. consent of the patient or legal guardian 2. 18 years or above 3. normal height and weight 4. ASA class I, II 5. elective surgery 6. surgery time within 60min 7. understanding of the verbal numerical rating score (0-10)

Exclusion criteria

1. history of ocular surgery, trauma or infection 2. intraoperative complications 3. glaucoma or ocular hypertension (\> 20 mmHg) 4. diabetic retinopathy 5. diagnosis of asthma or coagulopathy 6. chronic pain syndromes 7. history of peptic ulceration, liver or hematologic disease 8. history of chronic use of analgesics, sedatives, opioids or steroids 9. history of drug or alcohol abuse 10. history of systemic disease 11. sexually transmitted disease (STD) 12. Pregnancy, lactation; 13. cognitive impairment or psychiatric illness;

Design outcomes

Primary

Measure	Time frame
Pain score using numerical rating scale (NRS)	preoperative

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 27, 2026