Effects of Gonadotropin Replacement Therapy on Metabolic Parameters in Patients With Hypogonadism

Lipid Profile and Oxidative Stress Parameters of Patients With Idiopathic Hypogonadotropic Hypogonadism and the Change of These Parameters With Gonadotropin Replacement Therapy

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02728440

Enrollment

Registered

2016-04-05

Start date

2010-05-31

Completion date

2012-12-31

Last updated

2016-04-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Idiopathic Hypogonadotropic Hypogonadism

Brief summary

Effects of gonadotrophin replacement therapy Lipid Profile and Oxidative Stress Parameters of Patients with Idiopathic Hypogonadotropic Hypogonadism

Detailed description

30 male patients diagnosed with IHH and a control group of 20 healthy cases with similar age and BMI were included in the study. The levels of advanced oxidation protein products (AOPP), thiol, malondialdehyde (MDA), nitric oxide (NO) and 8-hydroxydeoxyguanosine (8-OHdG) and the levels of triglyceride (TG), total cholesterol (TC), high density lipoprotein (HDL-K), low density lipoprotein (LDL-K), Apolipoprotein A1 (ApoA1) and Apolipoprotein B100 (ApoB100) were measured before and after gonadotrophin therapy.

Interventions

DRUGhuman chorionic gonadotropin, human menopausal gonadotropin

drug for the treatment of male hypogonadism

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

MALE

Age

22 Years to 35 Years

Healthy volunteers

Yes

Inclusion criteria

Serum testosterone concentration \< 300ng/dL Absence of a pituitary or hypothalamic mass lesions, Presence of gonadotropin response to GnRH, -

Exclusion criteria

diabetes mellitus, arterial hypertension other hormone deficiencies \-

Design outcomes

Primary

Measure	Time frame
oxidative stress after hCG and HMG treatment	2010-2012
HDL levels after hCG treatment	2010-2012
total cholesterole levels after hCG treatment	2010-2012

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026