Iron Deficiency
Conditions
Brief summary
Iron deficiency affects the opioid and dopamine systems in rodent models, with a higher pain threshold. The opioid system is involved in sucrose's ability to reduce pain and distress during neonatal procedures. Thus, prenatal iron deficiency might affect response to pain and sucrose analgesia. In order to compare response to pain and sucrose during heel stick in neonates with and without iron deficiency, healthy full-term Chinese infants were randomized to receive sucrose or water by syringe beforehand, in conjunction with heel stick for metabolic screening.
Interventions
OTHERWater
2 ml distilled water by syringe one time in the newborn's mouth 2 minutes before heel stick
OTHERSucrose
2 ml 25% sucrose in distilled water by syringe one time in the newborn's mouth 2 minutes before heel stick
Sponsors
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Study design
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
1 Days to 5 Days
Healthy volunteers
No
Inclusion criteria
* Full term healthy neonates participating in the Healthy Infant Development RCT (NCT00613717) in the folic acid/early postnatal placebo group and pre- and early postnatal iron-supplemented infants.
Exclusion criteria
* birth weight \< 2500 g gestational age ≤ 37 wk major perinatal complications major congenital anomaly multiple birth
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Infant behavior (emotion regulation) | up to 5 days old | Infant behavior observed included activity level, negative emotionality, alertness and soothability. |
Countries
China
Outcome results
None listed