Tissue Perfusion Indices as Predictor of Outcome in Poly Trauma Patients

Central Venous-arterial Carbon Dioxide Pressure Difference in Correlation to Dynamic Changes of Serum Lactate as an Indicator of Tissue Perfusion in Polytruama Patients

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02727946

Enrollment

Registered

2016-04-05

Start date

2016-05-31

Completion date

2018-01-31

Last updated

2016-09-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Multiple Trauma

Brief summary

Early intervention and resuscitation based upon a lot of clinical, laboratory findings make a big difference regarding outcome in poly trauma patients, the study uses the dynamic lactate change and the difference between arterial and venous CO2, oxygen tension or content as indicators for tissue perfusion.

Detailed description

Poly trauma patients have high incidence of mortality and morbidity in spite of improvements and advances in facilities. However, no doubt that early resuscitation and interventions make a big difference upon the overall outcome. A lot of methods, indices, laboratory and biomarkers have been utilized to evaluate the progress and quality of resuscitation and the early hospital interventions in such group of critically ill patients including central venous pressures, urine output, mixed venous oxygen saturation, and gastric tonometry. Most of recent means focus upon the regional tissue perfusion rather than global, however some researches have tried the difference between arterial and venous CO2,oxygen tension or content ( Pv -a co2& Pa -v O2 ) in addition to dynamic changes in lactate(3) as predictors for tissue perfusion in sepsis patients after establishment of sepsis campaign (bundle).

Interventions

OTHERoptimal resuscitation

optimal resuscitation to achieve mean arterial blood pressure above 65 mmHG , Central venous pressure more than 8 mmHg , urine out put more than 0.5 ml /Kg/hour

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

SUPPORTIVE_CARE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 40 Years

Healthy volunteers

Inclusion criteria

* multiple trauma patients Adult patients

Exclusion criteria

* cardiac renal chronic chest disease diabetic more than 3 years

Design outcomes

Primary

Measure	Time frame	Description
the difference between partial pressure of oxygen in arterial and venous blood	6 hours	—
the difference between partial pressure of carbon dioxide in arterial and venous blood	6 hours	—
serum level of lactate and its changes	6 hours	as an index for tissue oxygenation

Secondary

Measure	Time frame	Description
Kidney function	72 hours	serum creatinine in mg/ dl and urine output/ hour
hemodynamic stability including pulse rate and mean arterial blood pressure	72 hours	—
duration of stay in the critical care unit	72 hours	—

Countries

Egypt

Contacts

Primary ContactEmad Zarief Kamel Said, MD

emadzarief@yahoo.com00201007046058

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026