Cardiovascular Disease, Myocardial Fibrosis
Conditions
Brief summary
* The purpose of this study is to show that the novel TRAMINER (T(Rho) and Magnetization Transfer and Inversion Recovery) sequence provides at least as good visualization and detection of sub-endocardial scarring, fibrosis, and acute infarction as the current gold standard Inversion Recovery (IR) Turbo-Flash sequence. * The hypothesis is that the TRAMINER sequence has the same or higher sensitivity in detecting small sub-endocardial scarring than the inversion recovery segmented gradient echo sequence known as IR-Turbo Fast low angle shot (IR Turbo-Flash), which is the accepted current gold standard for the detection of myocardial viability.
Interventions
OTHERTraminer MRI Sequence
The Traminer MRI sequence will be added to the standard IR Turbo-Flash sequence and last 2-5 minutes.
Sponsors
Siemens Corporation, Corporate Technology
Wake Forest University Health Sciences
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adults ≥18 years of age referred for a cardiac MRI with Gadolinium enhancement only at Advocate Lutheran General Hospital
Exclusion criteria
* \<18 years old, * Adults unable to consent * Adults for whom the MRI has not been previously scheduled * Adults with an order for any MRI other than cardiac MRI with Gadolinium enhancement
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Sensitivity of the TRAMINER sequence in detecting myocardial fibrosis or acute infarction compared to the gold standard sequence will be measured. | 6-12 months | The method of assessment is through a score using the 17 segment model of myocardial map. |
Secondary
| Measure | Time frame |
|---|---|
| Reduction in clinical Magnetic Resonance (MRI) procedure time. | 6-12 months |
Countries
United States
Outcome results
None listed