Acute Exercise and Microvascular Function

Influence of Acute Exhausting Exercise on Microvascular Reactivity in Healthy Sedentary Subjects and Athletes

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02727439

Enrollment

Registered

2016-04-04

Start date

2016-02-29

Completion date

2017-12-31

Last updated

2016-04-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Physical Exertion

Keywords

microvascular function, laser Doppler flowmetry, exercise

Brief summary

It is well recognized that chronic exercise protects against the development of cardiovascular diseases. However, the responses of vasculature to acute exercise (AE) are not well known and not consistent in literature. Acute exertional exercise can induce large, transient increases in arterial pressure and development of metabolic acidosis which can be associated with pro-inflammatory response involving oxidant stress and circulating cytokines known to impair endothelial function. The aim of this study is to test the impact of a single exposure to exhausting training on microvascular reactivity in healthy sedentary subjects and athletes.

Interventions

OTHERAcute Exhausting Exercise (AE)

A single progressive rowing training to maximal exhaustion (AE).

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 30 Years

Healthy volunteers

Yes

Inclusion criteria

* healthy volunteers * active athletes * lean sedentary subjects

Exclusion criteria

* drugs that could affect the endothelium * overweight * hypertension * coronary artery disease * diabetes * hyperlipidaemia * renal impairment * cerebrovascular and peripheral artery disease

Design outcomes

Primary

Measure	Time frame	Description
Skin microcirculation post occlusive reactive hyperemia	Post occlusive reactive hyperemia - PORH, recorded by Laser Doppler Flowmetry will be measured immediately after acute exhausting training.	Cutaneous microvascular blood flow will be measured by Laser Doppler Flowmetry in response to vascular occlusion (post occlusive reactive hyperemia - PORH) before and after acute exhausting training.
Skin microcirculation acetylcholine induced dilation	Acetylcholine induced dilation (AChID), recorded by Laser Doppler Flowmetry will be measured immediately after acute exhausting training.	Cutaneous microvascular blood flow will be measured by Laser Doppler Flowmetry in response to iontophoresis of acetylcholine (acetylcholine induced dilation, AChID) before and after acute exhausting training.

Countries

Croatia

Contacts

Primary ContactAna Stupin, MD, PhD

anacavka@mefos.hr+385915134958

Backup ContactInes Drenjancevic, MD, PhD

ines.drenjancevic@mefos.hr+385912241406

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026