Epilepsy
Conditions
Brief summary
The purpose of this randomized uncontrolled single-site trial is to evaluate the efficacy of two novel computerized cognitive enhancing software packages for improving cognitive and behavioral outcomes in patients with epilepsy.
Detailed description
The proposed investigation will be the first to pit two software packages against each other to evaluate the relative efficacy and feasibility of their use among patients with epilepsy. Pharmacotherapy fails to control seizures in approximately 30% of patients. Use of non-pharmacologic interventions, such as cognitive rehabilitation, has shown some benefit for improving cognitive functions and reducing mood symptoms. Each of the computer exercises employ a set of stimuli that are generalizable and mimic real-world experiences.
Interventions
BEHAVIORALMemory Match Exercise
BEHAVIORALMemory Matrix Exercise
BEHAVIORALFamiliar Faces Exercises
BEHAVIORALLost in Migration Exercise
BEHAVIORALPlaying Koi Exercise
BEHAVIORALTriad-FiguresExercise
BEHAVIORALMonster Garden Exercise
BEHAVIORALSpatial Match Exercise
BEHAVIORALTemporal Sequence Reconstruction Exercise
BEHAVIORALToken Task Exercise
BEHAVIORALStory Recall Exercise
BEHAVIORALSample-Match (Within Modality) Exercise
BEHAVIORALPair-Match (Across-Modality) Exercise
Sponsors
NYU Langone Health
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* Documented diagnosis of epilepsy based on medical records. The records will be reviewed by the PI and the approved study personnel to confirm that a diagnosis of epilepsy has been made. * Must own a computer or have access to the internet.
Exclusion criteria
* Full Scale IQ \< 80, as assessed by the WASI-II. * History of chronic progressive neurologic or neurodegenerative illnesses (e.g., Parkinson's disease, multiple sclerosis, dementia, primary or metastatic malignancy). Patients with headache or migraine are not excluded. * History of Axis I psychiatric illness with psychotic features. (e.g., schizophrenia). Patients with depression or anxiety (treated or untreated) without psychotic features are not excluded. * Visual or auditory impairment, which precludes participation in part, or all of the testing. * English as a first language will not be required, but participants must have either received some of their schooling in English or used English in their work for \>10 years.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total Index Score from the Repeatable Battery for the Assessment of Neurocognitive Status (RBANS) | 8 Weeks |
Secondary
| Measure | Time frame |
|---|---|
| The Everyday Cognition Scale (ECog) | 8 Weeks |
| Perceived cognitive abilities on an index of subjective cognitive abilities (Cognitive Self-Report Questionnaire; CSRQ-25) | 8 Weeks |
| Measure of mood (Geriatric Depression Scale) | 8 Weeks |
Countries
United States
Outcome results
None listed