Effects of Sleep Deprivation on Diaphragm Command During an Inspiratory Endurance Trial in Healthy Volunteers.

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02725190

Acronym

NoSleepDiaph

Enrollment

Registered

2016-03-31

Start date

2016-04-30

Completion date

2017-12-31

Last updated

2017-12-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diaphragm, Healthy Volunteers, Sleep Deprivation

Brief summary

The purpose of this study is to assess the impact of sleep deprivation on subjective inspiratory endurance in healthy subjects.

Detailed description

Sleep in intensive care unit is altered and few studies have suggested that sleep deprivation (SD) could impact respiratory muscle endurance. A lack of inspiratory endurance could lengthen weaning from invasive ventilation. The purpose of this study is to confirm whether SD alters inspiratory endurance and to identify brain mechanisms involved in SD-induced decreased endurance. A group of 20 male healthy subjects will perform an inspiratory load trial after a normal sleep night and after a sleepless night. Electrophysiological parameters (EEG, motor evoked potentials) of the inspiratory motor command and sensory perceptions will be assessed before, during and after each trial.

Interventions

BEHAVIORALSleepless night

Each subject will undergo 28 hours of sleep deprivation.

BEHAVIORALNormal sleep night

Normal sleep at home before trial.

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

SINGLE (Investigator)

Eligibility

Sex/Gender

MALE

Age

25 Years to 45 Years

Healthy volunteers

Yes

Inclusion criteria

* Male adult volunteers * Aged 25 to 45 years * Regularly sleeping more than 6 hours per night * Not excessive coffee consumers (\< 3 expressos / day) * Non smokers * Absence of respiratory, cardiac, muscular or neurological disease or diabetes * With a neutral Horne & Ostberg score

Exclusion criteria

* Previous history of respiratory disease or otorhinolaryngological (asthma, respiratory allergies, swallowing disorders, oropharyngeal malformations) * History of epilepsy or syncope during sleep deprivation * Taking medications that interfere with sleep (antidepressants, benzodiazepines…)

Design outcomes

Primary

Measure	Time frame
Time, in minutes, measured from the beginning of the inspiratory endurance test and the end, defined by the patient's wish to stop.	The day after one normal night or one sleepless night.

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 15, 2026