E-Cigarettes and SNA

The Effects of Electronic Cigarettes on Sympathetic Nerve Activity and Oxidative Stress

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02724241

Enrollment

100

Registered

2016-03-31

Start date

2015-04-30

Completion date

2021-12-31

Last updated

2021-12-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nicotine Dependence

Keywords

nicotine, autonomic tone, oxidative stress

Brief summary

Randomized controlled trial of electronic cigarettes with nicotine, without nicotine, and sham control, on sympathetic nerve activity and markers of oxidative stress.

Detailed description

Participants will use an electronic cigarette on 3 occasions: 1) with nicotine, 2) without nicotine, 3) sham control, and measures of autonomic tone, including heart rate variability (HRV) and sympathetic nerve activity (MSNA: microneurography), and oxidative stress will be measured pre and post exposure.

Interventions

OTHERone time exposure to e-cig with nicotine

one time exposure to e-cigarette vapor with nicotine

OTHEROne time exposure to e-cigarette without nicotine

One time exposure to e-cig without nicotine

OTHERone time exposure to empty e-cigarette

one time exposure to empty e-cigarette (sham control)

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

21 Years to 45 Years

Healthy volunteers

Yes

Inclusion criteria

Healthy

Exclusion criteria

* Cardiac disease * Respiratory disease * Diabetes mellitus

Design outcomes

Primary

Measure	Time frame	Description
Heart Rate variability	10 minutes after exposure	Heart rate variability is a measure of autonomic tone
Paraoxonase	less than 1 hour after exposure	plasma oxidative stress

Secondary

Measure	Time frame	Description
muscle sympathetic nerve activity	10 minutes after exposure	Muscle sympathetic nerve activity (MSNA)

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026